Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Amyloid precursor proteins inhibit heme oxygenase activity and augment neurotoxicity in Alzheimer's disease
Autore:
Takahashi, M; Dore, S; Ferris, CD; Tomita, T; Sawa, A; Wolosker, H; Borchelt, DR; Iwatsubo, T; Kim, SH; Thinakaran, G; Sisodia, SS; Snyder, SH;
Indirizzi:
Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 urosci, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Med, Dept Anesthesiol Crit Care Med, Baltimore, MD21205 USA Johns Hopkins Univ Baltimore MD USA 21205 are Med, Baltimore, MD21205 USA Johns Hopkins Univ, Sch Med, Dept Med, Div Gastroenterol, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 nterol, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 Pathol, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Med, Dept Pharmacol & Mol Sci, Baltimore, MD 21205USA Johns Hopkins Univ Baltimore MD USA 21205 Mol Sci, Baltimore, MD 21205USA Johns Hopkins Univ, Sch Med, Dept Psychiat, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 ychiat, Baltimore, MD 21205 USA Univ Tokyo, Fac Pharmaceut Sci, Dept Neuropathol & Neurosci, Tokyo 113, Japan Univ Tokyo Tokyo Japan 113 Dept Neuropathol & Neurosci, Tokyo 113, Japan Univ Chicago, Dept Neurobiol Pharmacol & Physiol, Chicago, IL 60637 USA Univ Chicago Chicago IL USA 60637 rmacol & Physiol, Chicago, IL 60637 USA
Titolo Testata:
NEURON
fascicolo: 2, volume: 28, anno: 2000,
pagine: 461 - 473
SICI:
0896-6273(200011)28:2<461:APPIHO>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSGENIC MICE; OXIDATIVE STRESS; BETA-PROTEIN; IN-VITRO; MOLECULAR-CLONING; CARBON-MONOXIDE; EXPRESSION; BRAIN; IRON; TOXICITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
68
Recensione:
Indirizzi per estratti:
Indirizzo: Snyder, SH Johns Hopkins Univ, Sch Med, Dept Neurosci, 725 N Wolfe St, Baltimore, MD 21205 USA Johns Hopkins Univ 725 N Wolfe St Baltimore MD USA 21205 05 USA
Citazione:
M. Takahashi et al., "Amyloid precursor proteins inhibit heme oxygenase activity and augment neurotoxicity in Alzheimer's disease", NEURON, 28(2), 2000, pp. 461-473

Abstract

Amyloid precursor protein (APP) generates the beta -amyloid peptide, postulated to participate in the neurotoxicity of Alzheimer's disease. We reportthat APP and APLP bind to heme oxygenase (HO), an enzyme whose product, bilirubin, is antioxidant and neuroprotective. The binding of APP inhibits HOactivity, and APP with mutations linked to the familiar Alzheimer's disease (FAD) provides substantially greater inhibition of HO activity than wild-type APP. Cortical cultures from transgenic mice expressing Swedish mutant APP have greatly reduced bilirubin levels, establishing that mutant APP inhibits HO activity in vivo. Oxidative neurotoxicity is markedly greater in cerebral cortical cultures from APP Swedish mutant transgenic mice than wild-type cultures. These findings indicate that augmented neurotoxicity causedby APP-HO interactions may contribute to neuronal cell death in Alzheimer's disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 20:32:13