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Titolo:
A multicenter assessment of dopamine transporter imaging with DOPASCAN/SPECT in parkinsonism
Autore:
Marek, K; Seibyl, J; Holloway, R; Kieburtz, K; Oakes, D; Lang, A; Yim, J; Dey, H; Cellar, J; Fussell, B; Broshjeit, S; Early, M; Smith, EO; Sudarsky, L; Johnson, KA; Corwin, C; Johnson, D; Lajoie, S; Reich, SG; Frost, JJ; Goldberg, P; Flesher, JE; Feigin, A; Mazurkiewicz, J; Castronuovo, J; Joseph, F; DiRocco, A; Olanow, CW; Machac, J; Cotei, D; Webner, P; Rudolph, A; Day, D; Casaceli, C; Freimuth, A; Orme, C; Hodgeman, K; Eberly, S; Henry, E; Morgan, G; Haley, JB; Henry, E;
Indirizzi:
Yale Univ, Sch Med, Dept Neurol, New Haven, CT 06510 USA Yale Univ New Haven CT USA 06510 ed, Dept Neurol, New Haven, CT 06510 USA Univ Rochester, Rochester, NY 14627 USA Univ Rochester Rochester NY USA 14627 Rochester, Rochester, NY 14627 USA Toronto Western Hosp, Toronto, ON M5T 2S8, Canada Toronto Western Hosp Toronto ON Canada M5T 2S8 oronto, ON M5T 2S8, Canada Johns Hopkins Univ, Sch Med, Baltimore, MD 21218 USA Johns Hopkins Univ Baltimore MD USA 21218 ch Med, Baltimore, MD 21218 USA N Shore Univ Hosp, Manhasset, NY USA N Shore Univ Hosp Manhasset NY USAN Shore Univ Hosp, Manhasset, NY USA Mt Sinai Med Ctr, New York, NY 10029 USA Mt Sinai Med Ctr New York NY USA10029 ai Med Ctr, New York, NY 10029 USA
Titolo Testata:
NEUROLOGY
fascicolo: 10, volume: 55, anno: 2000,
pagine: 1540 - 1547
SICI:
0028-3878(20001128)55:10<1540:AMAODT>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRESSIVE SUPRANUCLEAR PALSY; POSITRON EMISSION TOMOGRAPHY; ESSENTIAL TREMOR; DISEASE; SPECT; IODINE-123-BETA-CIT; DIAGNOSIS; STRIATUM; BINDING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Marek, K Yale Univ, Sch Med, Dept Neurol, 40 Temple St,Suite 6C, New Haven, CT 06510 USA Yale Univ 40 Temple St,Suite 6C New Haven CT USA 06510 06510 USA
Citazione:
K. Marek et al., "A multicenter assessment of dopamine transporter imaging with DOPASCAN/SPECT in parkinsonism", NEUROLOGY, 55(10), 2000, pp. 1540-1547

Abstract

Background: In vivo imaging of the dopamine transporter (DAT) with SPECT is a quantitative biomarker for PD onset and severity. Objective: To use a multicenter study to evaluate the diagnostic accuracy of DOPASCAN and SPECT in patients with PD, progressive supranuclear palsy (PSP), and essential tremor (ET), and in healthy controls (HC. Methods: Ninety-six individuals with known clinical diagnosis were imaged with DOPASCAN at five sites with different multidetector SPECT systems. Both masked visual interpretation and region of interest (ROI) analysis were performed at each site and at a core analysis center. Results: Visual interpretation of the images by an expert panel demonstrated a sensitivity of 0.98 and specificity of 0.83 comparing parkinsonian (PD + PSP) versus nonparkinsonian (ET + HC) controls. Quantitative analysis of putamen and caudate DOPASCAN uptake for each region in thePD or PSP groups was significantly reduced compared to the ET or HC groups. Comparison of parkinsonian (PD + PSP) versus nonparkinsonian (ET + HC) individuals demonstrated a reduction of 76% in mean putamen and 48% in mean caudate DOPASCAN uptake. Conclusions: DOPASCAN and SPECT imaging reliably and effectively distinguish between subjects with Parkinson's syndrome (PD + PSP) and without Parkinson's syndrome (RC + ET). This is the first multicenter assessment of dopamine transporter imaging demonstrating that this toolmay be used widely to assess dopaminergic degeneration in patients with parkinsonism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 12:10:50