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Titolo:
Acamprosate inhibits Ca2+ influx mediated by NMDA receptors and voltage-sensitive Ca2+ channels in cultured rat mesencephalic neurones
Autore:
Allgaier, C; Franke, H; Sobottka, H; Scheibler, P;
Indirizzi:
Univ Leipzig, Rudolf Boehm Inst Pharmakol & Toxikol, D-04107 Leipzig, Germany Univ Leipzig Leipzig Germany D-04107 & Toxikol, D-04107 Leipzig, Germany
Titolo Testata:
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
fascicolo: 4-5, volume: 362, anno: 2000,
pagine: 440 - 443
SICI:
0028-1298(200011)362:4-5<440:AICIMB>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALCOHOL DEPENDENCE; ETHANOL; NEUROTRANSMISSION; INVOLVEMENT;
Keywords:
acamprosate; NMDA receptor; voltage-dependent Ca2+ channels; omega-conotoxin MVIIC; fura-2; intracellular Ca2+ concentration; cultured mesencephalic neurones;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Allgaier, C Univ Leipzig, Rudolf Boehm Inst Pharmakol & Toxikol, Hartelstr16-18, D-04107 Leipzig, Germany Univ Leipzig Hartelstr 16-18 Leipzig Germany D-04107 Germany
Citazione:
C. Allgaier et al., "Acamprosate inhibits Ca2+ influx mediated by NMDA receptors and voltage-sensitive Ca2+ channels in cultured rat mesencephalic neurones", N-S ARCH PH, 362(4-5), 2000, pp. 440-443

Abstract

Acamprosate has recently been introduced in relapse prophylaxis in weaned alcoholics. Using fura-2 microfluorimetry, the present study investigates whether acamprosate affects N-methyl-D-aspartate (NMDA) or K+-induced changes in free intracellular Ca2+ concentration ([Ca2+](i)) in rat cultured mesencephalic neurones. Both application of NMDA (plus glycine) and elevation of extracellular K+ induced rapid increases in [Ca2+](i) which respectively were insensitive and sensitive to omega -conotoxin (omega -CTX) MVIIC, a blocker of voltage-dependent Ca2+ channels (VDCCs). Acamprosate (100 muM and 300 muM) significantly attenuated the response induced by NMDA as well as that induced by K+ in a concentration-dependent manner. Concurrent application of omega -CTX MVIIC and acamprosate impaired the K+-induced increase in [Ca2+](i) to the same extent as omega -CTX MVIIC alone. The present data suggest that acamprosate inhibits Ca2+ influx through both NMDA receptors andVDCCs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 02:07:41