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Titolo:
Fibrillin: from domain structure to supramolecular assembly
Autore:
Handford, PA; Downing, AK; Reinhardt, DP; Sakai, LY;
Indirizzi:
Oregon Hlth Sci Univ, Shriners Hosp Children, Dept Biochem & Mol Biol, Portland, OR 97201 USA Oregon Hlth Sci Univ Portland OR USA 97201 l Biol, Portland, OR 97201 USA Univ Oxford, Dept Biochem, Div Mol & Cellular Biochem, Oxford OX1 3QU, England Univ Oxford Oxford England OX1 3QU ular Biochem, Oxford OX1 3QU, England Univ Oxford, Dept Biochem, Div Struct Biol, Oxford OX1 3QU, England Univ Oxford Oxford England OX1 3QU Struct Biol, Oxford OX1 3QU, England Univ Lubeck, Dept Med Mol Biol, D-23562 Lubeck, Germany Univ Lubeck Lubeck Germany D-23562 Med Mol Biol, D-23562 Lubeck, Germany
Titolo Testata:
MATRIX BIOLOGY
fascicolo: 6, volume: 19, anno: 2000,
pagine: 457 - 470
SICI:
0945-053X(200011)19:6<457:FFDSTS>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR-BETA; CALCIUM-BINDING PROPERTIES; DEPENDENT PROTEIN-S; MARFAN-SYNDROME; TERMINAL SEQUENCES; 8-CYSTEINE REPEAT; MICROFIBRILS; ORGANIZATION; MATRIX; GENE;
Keywords:
structure; function; fibrillin;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Sakai, LY Oregon Hlth Sci Univ, Shriners Hosp Children, Dept Biochem & MolBiol, Portland, OR 97201 USA Oregon Hlth Sci Univ Portland OR USA 97201 rtland, OR 97201 USA
Citazione:
P.A. Handford et al., "Fibrillin: from domain structure to supramolecular assembly", MATRIX BIOL, 19(6), 2000, pp. 457-470

Abstract

In the last 5 years, significant progress has been made in understanding the structure and function of all the major domains composing the fibrillins. A previous review [Meth. Enzymol. 245 (1994), 29] focused on the isolation of fibrillin monomers and fibrillin-containing polymers (microfibrils). In this article, information gained from recent studies which have further elucidated molecular structure and investigated effects of mutations on structural and functional properties will be summarized. In addition, studies of functional domains in fibrillins which may be important in assembling microfibrils will be discussed. Throughout this review, the authors have attempted to identify areas of research which have been controversial. In the conclusion, we raise important questions which remain unresolved. (C) 2000 Elsevier Science B.V./International Society of Matrix Biology. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 03:32:54