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Titolo:
Brugada syndrome without mutation of the cardiac sodium channel gene in a Taiwanese patient
Autore:
Chen, SM; Kuo, CT; Lin, KH; Chiang, FT;
Indirizzi:
Chang Gung Mem Hosp, Dept Internal Med, Cardiovasc Div 1, Taipei 10591, Taiwan Chang Gung Mem Hosp Taipei Taiwan 10591 vasc Div 1, Taipei 10591, Taiwan Chang Gung Univ, Taipei, Taiwan Chang Gung Univ Taipei TaiwanChang Gung Univ, Taipei, Taiwan Natl Taiwan Univ Hosp, Dept Lab Med & Internal Med, Taipei, Taiwan Natl Taiwan Univ Hosp Taipei Taiwan Med & Internal Med, Taipei, Taiwan
Titolo Testata:
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
fascicolo: 11, volume: 99, anno: 2000,
pagine: 860 - 862
SICI:
0929-6646(200011)99:11<860:BSWMOT>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
ST SEGMENT ELEVATION; MECHANISM;
Keywords:
sudden cardiac death; Brugada syndrome; SCN5A;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
7
Recensione:
Indirizzi per estratti:
Indirizzo: Kuo, CT Chang Gung Mem Hosp, Dept Internal Med, Cardiovasc Div 1, 199 TungHwa N Rd, Taipei 10591, Taiwan Chang Gung Mem Hosp 199 Tung Hwa N Rd Taipei Taiwan 10591 Taiwan
Citazione:
S.M. Chen et al., "Brugada syndrome without mutation of the cardiac sodium channel gene in a Taiwanese patient", J FORMOS ME, 99(11), 2000, pp. 860-862

Abstract

We describe a 45-year-old Taiwanese man with specific features of Brugada syndrome but no clinical features of structural heart disease. He was successfully, treated with an implantable cardioverter-defibrillator. His electrocardiogram (ECG) patterns changed intermittently. Alpha-adrenoceptor stimulation and beta-adrenoceptor blockade augmented the characteristic ST-segment elevation, whereas alpha-adrenoceptor blockade and beta-adrenoceptor stimulation mitigated the ST-segment elevation, intravenous procainamide administration did not aggravate ST-segment elevation when ECG had shown coved ST elevation in the right precordial leads. Molecular study did not reveal the same mutations in the cardiac sodium channel gene (SCN5A) as previously reported in Brugada syndrome. This case demonstrates the genetic heterogeneity of SCN5A in Brugada syndrome.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 14:23:14