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Titolo:
Relationship between the concentration of CDDP in tumor and tumor size after isolated lung perfusion treatment experimental study on a solitary pulmonary sarcoma model in rats
Autore:
Saeki, K; Kaneda, Y; Li, TS; Ueda, K; Esato, K;
Indirizzi:
Yamaguchi Univ, Sch Med, Dept Surg 1, Yamaguchi 7558505, Japan Yamaguchi Univ Yamaguchi Japan 7558505 Surg 1, Yamaguchi 7558505, Japan
Titolo Testata:
JOURNAL OF SURGICAL ONCOLOGY
fascicolo: 3, volume: 75, anno: 2000,
pagine: 193 - 196
SICI:
0022-4790(200011)75:3<193:RBTCOC>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
SOFT-TISSUE SARCOMAS; NODULE MODEL; METASTASES; CHEMOTHERAPY; DOXORUBICIN; ESTABLISHMENT; SURVIVAL;
Keywords:
isolated lung perfusion; cisplatin; pharmacokinetics; tumor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Saeki, K Yamaguchi Univ, Sch Med, Dept Surg 1, 1144 Kogushi, Yamaguchi 7558505, Japan Yamaguchi Univ 1144 Kogushi Yamaguchi Japan 7558505 58505, Japan
Citazione:
K. Saeki et al., "Relationship between the concentration of CDDP in tumor and tumor size after isolated lung perfusion treatment experimental study on a solitary pulmonary sarcoma model in rats", J SURG ONC, 75(3), 2000, pp. 193-196

Abstract

Background and Objectives: Few investigations on the pharmacokinetics of isolated lung perfusion (ILP) regional chemotherapy in tumors have been conducted. The purpose of this study was to evaluate the pharmacokinetic character of ILP in tumor tissues. Materials and Methods: A solitary tumor nodule model was established in Fisher 344 rats by inoculating 1.0 x 10(6) methylcholanthrene-induced sarcomacells into the left lung. On 14-21 days after the inoculation of tumor cells, rats were randomized into groups subjected to 10, 20, 40 or 60 min ILP with cis-diamminedichloroplatinum (CDDP) at concentrations of 25, 50, or 100 mug/ml. Total platinum concentration in tumors was measured by a flameless atomic absorption spectrophotometer. Results: The average tumor weights and total platinum concentrations were not significantly different among the perfusion groups. We found, however, that the total platinum concentrations in tumor nodules were significantly correlated inversely with the tumor weight (total platinum concentration intumor = 1.167 x 1/tumor wt; R-2 = 0.981; P < 0.001). Conclusions: The concentration of total platinum in the tumor tissue was found to be dependent on the weight of the tumor in ILP. Higher concentrations of total platinum were expressed in smaller tumor nodules than larger ones, indicating that ILP may be more effective against small tumors than large ones. Therefore, we suggest that large tumor legions should be debulked before ILP in patients with an unresectable lung tumor. J. Surg. Oncol. 2000;75:193-196. (C) 2000 Wiley-Liss, Inc.

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Documento generato il 01/12/20 alle ore 22:28:28