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Titolo:
Initiation of microvascular protection by nitric oxide in late preconditioning
Autore:
Wang, WZ; Anderson, GL; Guo, SZ; Tsai, TM; Miller, FN;
Indirizzi:
Univ Nevada, Sch Med, Dept Surg, Div Plast Surg, Las Vegas, NV 89102 USA Univ Nevada Las Vegas NV USA 89102 iv Plast Surg, Las Vegas, NV 89102 USA
Titolo Testata:
JOURNAL OF RECONSTRUCTIVE MICROSURGERY
fascicolo: 8, volume: 16, anno: 2000,
pagine: 621 - 628
SICI:
0743-684X(200011)16:8<621:IOMPBN>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
DENERVATED SKELETAL-MUSCLE; RAT CREMASTER MUSCLE; CAPILLARY NO-REFLOW; MYOCARDIAL PROTECTION; SUBLETHAL ISCHEMIA; REPERFUSION; ISCHEMIA/REPERFUSION; ADENOSINE; PROTEIN; INJURY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Wang, WZ Univ Nevada, Sch Med, Dept Surg, Div Plast Surg, 2040 W Charleston Blvd,Suite 601, Las Vegas, NV 89102 USA Univ Nevada 2040 W Charleston Blvd,Suite 601 Las Vegas NV USA 89102
Citazione:
W.Z. Wang et al., "Initiation of microvascular protection by nitric oxide in late preconditioning", J RECON MIC, 16(8), 2000, pp. 621-628

Abstract

The authors hypothesized that nitric oxide is induced by a brief period ofischemia/reperfusion (ischemic preconditioning, IPC) on postoperative day (POD) 1, and that this released nitric oxide is responsible for initiating a delayed microvascular protection against a prolonged period of ischemia in skeletal muscle on POD day 2. The cremaster muscle of male Sprague-Dawleyrats underwent 4 hr of ischemia, and then 60 min of reperfusion. IPC consisted of 45 min of ischemia but was done 24 hr before the prolonged ischemia. Local intraarterial infusion of sodium nitroprusside (SNP, a donor of nitric oxide) or N-w-nitro-(L)-arginine (L-NA, a nonselective nitric oxide synthase antagonist) were also given 24 hr before prolonged ischemia. Arteriole diameters and capillary perfusion were measured using intravital microscopy. Four groups were compared: 1) control; 2) IPC: 3) SNP + sham IPC; and 4) L-NA + IPC. Four hours of ischemia followed by reperfusion created a significant vasoconstriction and capillary no-reflow in the microcirculation ofcremaster muscles. These alterations were largely prevented by IPC. Local intraarterial infusion of SNP without IPC created a similar microvascular protection to that induced by IPC alone. In contrast, intraarterial infusionof L-NA prior to IPC eliminated the IPC-induced microvascular protection. In conclusion, in late preconditioning, nitric oxide contributes to the initiation of a delayed microvascular protection against prolonged ischemia inskeletal muscle.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:30:20