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Titolo:
FLUORESCENCE STUDY OF NEUROHYPOPHYSEAL HORMONES AND THEIR ANALOGS - DISTANCE DISTRIBUTIONS IN A SERIES OF ARGININE-VASOPRESSIN ANALOGS
Autore:
WICZK W; LANKIEWICZ L; KASPRZYKOWSKI F; OLDZIEJ S; SZMACINSKI H; LAKOWICZ JR; GRZONKA Z;
Indirizzi:
UNIV GDANSK,FAC CHEM,SOBIESKIEGO 18 PL-80952 GDANSK POLAND UNIV GDANSK,FAC CHEM PL-80952 GDANSK POLAND UNIV MARYLAND,SCH MED,DEPT BIOL CHEM,CTR FLUORESCENCE SPECT BALTIMOREMD 21201
Titolo Testata:
European biophysics journal
fascicolo: 2, volume: 26, anno: 1997,
pagine: 183 - 193
SICI:
0175-7571(1997)26:2<183:FSONHA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
TIME-RESOLVED FLUORESCENCE; FREQUENCY-DOMAIN FLUOROMETRY; PANCREATIC TRYPSIN-INHIBITOR; EMPIRICAL SOLVATION MODELS; RESONANCE ENERGY-TRANSFER; MULTIPLE-MINIMA PROBLEM; CONFORMATIONAL-ANALYSIS; MOLECULAR MECHANICS; TYROSYL RESIDUES; ECEPP POTENTIALS;
Keywords:
ARGININE-VASOPRESSIN ANALOGS; ENERGY TRANSFER; FLUORESCENCE QUENCHING; ACRYLAMIDE; MOLECULAR MECHANICS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
W. Wiczk et al., "FLUORESCENCE STUDY OF NEUROHYPOPHYSEAL HORMONES AND THEIR ANALOGS - DISTANCE DISTRIBUTIONS IN A SERIES OF ARGININE-VASOPRESSIN ANALOGS", European biophysics journal, 26(2), 1997, pp. 183-193

Abstract

Analogues of arginine-vasopressin (AVP) in which substitution of the proline residue in position 7 (by either sarcosine or N-methylalanine)combined with replacement of the cysteine residue in position 1 were the subject of a fluorescence and molecular mechanics study. We obtained two groups of analogues: selective antidiuretic agonists (cysteine or beta-mercaptopropionic acid in position 1) and presser and uterotonic antagonists (deamino-penicillamine or -mercapto-beta,beta-cyclopentamethylene-priopionic acid in position 1). Using frequency-domain measurements of fluorescence resonance energy transfer (FRET) we estimatedthe distance distribution between the phenolic ring of Tyr(2) and thedisulphide bridge Cys(1)-Cys(6). We also analyzed acrylamide quenching of tyrosyl fluorescence to determine the exposure of the tyrosyl ring to the solvent. Results from fluorescence experiments were compared with those from Monte Carlo simulation (ECEPP/3 force-field).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 16:38:24