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Titolo:
Depletion of a gamma delta T cell subset can increase host resistance to abacterial infection
Autore:
OBrien, RL; Yin, X; Huber, SA; Ikuta, K; Born, WK;
Indirizzi:
Natl Jewish Med & Res Ctr, Dept Immunol, Denver, CO 80206 USA Natl Jewish Med & Res Ctr Denver CO USA 80206 munol, Denver, CO 80206 USA Univ Colorado, Hlth Sci Ctr, Dept Immunol, Denver, CO 80262 USA Univ Colorado Denver CO USA 80262 Ctr, Dept Immunol, Denver, CO 80262 USA Univ Vermont, Dept Pathol, Burlington, VT 05405 USA Univ Vermont Burlington VT USA 05405 ept Pathol, Burlington, VT 05405 USA Kyoto Univ, Fac Med, Dept Med Chem, Kyoto 606, Japan Kyoto Univ Kyoto Japan 606 niv, Fac Med, Dept Med Chem, Kyoto 606, Japan
Titolo Testata:
JOURNAL OF IMMUNOLOGY
fascicolo: 11, volume: 165, anno: 2000,
pagine: 6472 - 6479
SICI:
0022-1767(200012)165:11<6472:DOAGDT>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
LISTERIA-MONOCYTOGENES; MONOCLONAL-ANTIBODY; MYCOBACTERIUM-TUBERCULOSIS; RECEPTOR REPERTOIRE; PROTECTIVE ROLE; LYMPHOCYTES-T; ALPHA-BETA; MICE; ANTIGEN; RECOGNITION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: O'Brien, RL Natl Jewish Med & Res Ctr, Dept Immunol, 1400 Jackson St, Denver, CO 80206USA Natl Jewish Med & Res Ctr 1400 Jackson St Denver CO USA 80206
Citazione:
R.L. O'Brien et al., "Depletion of a gamma delta T cell subset can increase host resistance to abacterial infection", J IMMUNOL, 165(11), 2000, pp. 6472-6479

Abstract

gamma delta T lymphocytes have been shown to regulate immune responses in diverse experimental systems. Because distinct gamma delta T cell subsets, as defined by the usage of certain TCR V genes, preferentially respond in various diseases and disease models, we have hypothesized that the various gamma delta T cell subsets carry out different functions. To test this, we compared one particular gamma delta T cell subset, the V gamma1(+) subset, which represents a major gamma delta T cell type in the lymphoid organs and blood of mice, to other subsets and to gamma delta T cells as a whole. Using Listeria monocytogenes infection as an infectious disease model, we foundthat bacterial containment improves in mice depleted of V gamma1(+) gamma delta T cells, albeit mice lacking all gamma delta T cells are instead impaired in their ability to control Listeria expansion. Our findings indicate that V gamma1(+) gamma delta T cells reduce the ability of the innate immune system to destroy Listeria, even though other gamma delta T cells as a whole promote clearance of this pathogen.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 07:07:47