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Titolo:
Congruence of mossy fiber and climbing fiber tactile projections in the lateral hemispheres of the rat cerebellum
Autore:
Brown, IE; Bower, JM;
Indirizzi:
CALTECH, Div Biol, Pasadena, CA 91125 USA CALTECH Pasadena CA USA 91125CALTECH, Div Biol, Pasadena, CA 91125 USA
Titolo Testata:
JOURNAL OF COMPARATIVE NEUROLOGY
fascicolo: 1, volume: 429, anno: 2001,
pagine: 59 - 70
SICI:
0021-9967(20010101)429:1<59:COMFAC>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
GRANULE CELL LAYER; PURKINJE-CELLS; OLIVOCEREBELLAR PROJECTION; RECEPTIVE-FIELDS; ORGANIZATION; CORTEX; CAT; RESPONSES; STIMULATION; TOPOGRAPHY;
Keywords:
Purkinje cell; granule cell; complex spike; simple spike; cerebellar cortex;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Brown, IE CALTECH, Div Biol, MC-216-76, Pasadena, CA 91125 USA CALTECH MC-216-76 Pasadena CA USA 91125 , Pasadena, CA 91125 USA
Citazione:
I.E. Brown e J.M. Bower, "Congruence of mossy fiber and climbing fiber tactile projections in the lateral hemispheres of the rat cerebellum", J COMP NEUR, 429(1), 2001, pp. 59-70

Abstract

We have examined the spatial relationship between the mossy fiber and climbing fiber projections to crus IIa in the lateral hemispheres of the rat cerebellum. Experiments were performed in ketamine/xylazine anesthetized ratsusing extracellular recordings and high-density micromapping techniques. Responses were elicited using small, tactile stimuli applied to the perioraland forelimb regions at a rate of 0.5 Hz. In our first series of experiments we demonstrate that the primary (i.e., strongest) receptive field for a single Purkinje cell's complex spike is similar to the primary receptive field of the granule cells immediately subjacent to that Purkinje cell. In our second series of experiments we demonstrate that the granule cell region most strongly activated by a particular peripheral stimulus is immediately subjacent to the Purkinje cells whose complex spikes are also activated most strongly by the same stimulus. The region of climbing fibers activated bya localized peripheral stimulus is "patchy"; it clearly does not conform to the notion of a continuous microzone. These results support original observations first reported in the 1960s using evoked potential recording techniques that the messy fiber and climbing fiber pathways converge in cerebellar cortex. However, we extend this earlier work to show that the two pathways converge at the level of single Purkinje cells. Many cerebellar theoriesassume that messy fiber and climbing fiber pathways carry information hem different peripheral locations or different modalities to cerebellar Purkinje cells. Our results appear to contradict this basic assumption for at least the tactile regions of the lateral hemispheres. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 22:25:52