Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Efficacy of polycationic peptides in preventing vascular graft infection due to Staphylococcus epidermidis
Autore:
Giacometti, A; Cirioni, O; Ghiselli, R; Goffi, L; Mocchegiani, F; Riva, A; Scalise, G; Saba, V;
Indirizzi:
Univ Ancona, INRCA IRCCS, Inst Infect Dis & Publ Hlth, Ancona, Italy Univ Ancona Ancona Italy CS, Inst Infect Dis & Publ Hlth, Ancona, Italy Univ Ancona, INRCA IRCCS, Dept Gen Surg, Ancona, Italy Univ Ancona Ancona Italy ona, INRCA IRCCS, Dept Gen Surg, Ancona, Italy
Titolo Testata:
Journal of antimicrobial chemotherapy
fascicolo: 5, volume: 46, anno: 2000,
pagine: 751 - 756
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-VITRO ACTIVITIES; ANTIMICROBIAL PEPTIDE; DACRON GRAFT; VANCOMYCIN; RESISTANCE; ANTIBIOTICS; SKIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Giacometti, A Azienda Osped Umberto 1, Piazza Cappelli 1, I-60121 Ancona, Italy Azienda Osped Umberto 1 Piazza Cappelli 1 Ancona Italy I-60121
Citazione:
A. Giacometti et al., "Efficacy of polycationic peptides in preventing vascular graft infection due to Staphylococcus epidermidis", J ANTIMICRO, 46(5), 2000, pp. 751-756

Abstract

A rat model was used to investigate the efficacy of two polycationic peptides, ranalexin and buforin II, in the prevention of vascular prosthetic graft infection due to methicillin-resistant Staphylococcus epidermidis with intermediate resistance to glycopeptides, The in vitro activity of the peptides was compared with those of vancomycin and teicoplanin by MIC determination and time-kill study. Moreover, the efficacy of collagen-sealed peptide-soaked Dacron was evaluated in a rat model of graft infection. Graft infections were established in the dorsal subcutaneous tissue of 120 adult male Wistar rats. The in vivo study included a control group, one contaminated group that did not receive any antibiotic prophylaxis and four contaminated groups that received an antibiotic-soaked graft. Experiments demonstrated that the activities of buforin II and ranalexin were greater than those of vancomycin and teicoplanin. Particularly, rats with buforin ii-coated Dacron grafts showed no evidence of staphylococcal infection while, for the rats with ranalexin-, vancomycin- and teicoplanin-coated Dacron grafts, the quantitative graft cultures demonstrated bacterial growth (1.9 x 10(2) +/- 0.6 x10(2) cfu/ml, 6.2 x 10(3) +/- 1.9 x 10(3) cfu/ml and 5.1 x 10(4) +/- 4.8 x10(3) cfu/ml, respectively), The study demonstrated that the use of peptide-soaked Dacron graft can result in significant bacterial growth inhibitionand indicates that these compounds may be potentially useful in prostheticsurgery.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 02:45:00