Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Green tea polyphenols inhibit the sodium-dependent glucose transporter of intestinal epithelial cells by a competitive mechanism
Autore:
Kobayashi, Y; Suzuki, M; Satsu, H; Arai, S; Hara, Y; Suzuki, K; Miyamoto, Y; Shimizu, M;
Indirizzi:
Univ Tokyo, Grad Sch Agr & Life Sci, Dept Appl Biol Chem, Bunkyo Ku, Tokyo1138657, Japan Univ Tokyo Tokyo Japan 1138657 Biol Chem, Bunkyo Ku, Tokyo1138657, Japan Mitsui Norin Co Ltd, Food Res Labs, Shizuoka 4260133, Japan Mitsui Norin Co Ltd Shizuoka Japan 4260133 Labs, Shizuoka 4260133, Japan Univ Shizouka, Grad Sch Food & Nutr Sci, Shizouka 4228526, Japan Univ Shizouka Shizouka Japan 4228526 & Nutr Sci, Shizouka 4228526, Japan
Titolo Testata:
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
fascicolo: 11, volume: 48, anno: 2000,
pagine: 5618 - 5623
SICI:
0021-8561(200011)48:11<5618:GTPITS>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRUSH-BORDER MEMBRANE; MEDICINAL FOODSTUFFS; GYMNEMA-SYLVESTRE; ABSORPTION; RAT; VESICLES; CATECHIN; ACID; (-)-EPIGALLOCATECHIN-3-GALLATE; CONSTITUENTS;
Keywords:
green tea; polyphenol; glucose transporter; intestinal cell; diabetes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Shimizu, M Univ Tokyo, Grad Sch Agr & Life Sci, Dept Appl Biol Chem, Bunkyo Ku, 1-1-1Yayoi, Tokyo 1138657, Japan Univ Tokyo 1-1-1 Yayoi Tokyo Japan 1138657 okyo 1138657, Japan
Citazione:
Y. Kobayashi et al., "Green tea polyphenols inhibit the sodium-dependent glucose transporter of intestinal epithelial cells by a competitive mechanism", J AGR FOOD, 48(11), 2000, pp. 5618-5623

Abstract

Intestinal glucose uptake is mainly performed by the sodium-dependent glucose transporter, SGLT1. The transport activity of SGLT1 was markedly inhibited by green tea polyphenols, this inhibitory activity being most pronounced in polyphenols having galloyl residues such as epicatechin gallate (ECg) and epigallocatechin gallate (EGCg). Experiments using brush-border membrane vesicles obtained from the rabbit small intestine demonstrated that ECg inhibited SGLT1 in a competitive manner, although ECg itself was not transported via SGLT1. The present results suggest that tea polyphenols such as ECg interact with SGLT1 as antagonist-like molecules, possibly playing a rolein controlling the dietary glucose uptake in the intestinal tract.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 11:27:46