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Titolo:
Hypermetaphase and interphase fluorescence in situ hybridisation for monitoring of remission status in Philadelphia chromosome positive chronic myeloid leukaemia
Autore:
Duba, HC; Hilbe, W; Mehringer, A; Erdel, M; Thaler, J; Utermann, G;
Indirizzi:
Innsbruck Univ, Inst Med Biol & Humangenet, A-6020 Innsbruck, Austria Innsbruck Univ Innsbruck Austria A-6020 genet, A-6020 Innsbruck, Austria Innsbruck Univ, Innere Med Klin, A-6020 Innsbruck, Austria Innsbruck UnivInnsbruck Austria A-6020 Klin, A-6020 Innsbruck, Austria
Titolo Testata:
INTERNATIONAL JOURNAL OF ONCOLOGY
fascicolo: 6, volume: 17, anno: 2000,
pagine: 1245 - 1249
SICI:
1019-6439(200012)17:6<1245:HAIFIS>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC MYELOGENOUS LEUKEMIA; PERIPHERAL-BLOOD; HEMATOLOGICAL MALIGNANCIES; INTERFERON-ALPHA; HYBRIDIZATION; CELLS; CYTOGENETICS; FISH; CML;
Keywords:
chronic myeloid leukaemia; fluorescence in situ hybridisation; interphase; hypermetaphase; remission assessment;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Duba, HC Innsbruck Univ, Inst Med Biol & Humangenet, Schopfstr 41, A-6020 Innsbruck, Austria Innsbruck Univ Schopfstr 41 Innsbruck Austria A-6020 ck, Austria
Citazione:
H.C. Duba et al., "Hypermetaphase and interphase fluorescence in situ hybridisation for monitoring of remission status in Philadelphia chromosome positive chronic myeloid leukaemia", INT J ONCOL, 17(6), 2000, pp. 1245-1249

Abstract

Interferon (IFN) alone or in combination with cytostatic drugs, can inducemajor and durable cytogenetic remissions in chronic myelogenous leukaemia (CML) patients. Hypermetaphase (HMF) and interphase (IPF) fluorescence in situ hybridisation (FISH) have been described to be suitable for remission assessment. In the present study we applied HMF and IPI: simultaneously to bone man ow (BM) probes from Ph-positive CML patients. hs conventional cytogenetics (CC) is still deemed to be the 'gold standard' for remission analysis we studied a group of patients analysed with this method as control . A mean of 50 metaphases was available for HMF analysis, whereas only an average of 18.7 metaphases could be analysed by CC. Remission assessment was frequently impossible by CC or HMF due to lack of metaphases, but always possible by applying IPF. Our results show that HMF should replace CC for routinely monitoring the remission status in Ph-positive CML patients and that incase of lack or insufficient number of metaphases in the majority of casesIPF is suitable fur remission assessment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 12:32:36