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Titolo:
Sildenafil citrate (Viagra (R)) is effective and well tolerated for treating erectile dysfunction of psychogenic or mixed aetiology
Autore:
Olsson, AM; Speakman, MJ; Dinsmore, WW; Giuliano, F; Gingell, C; Maytom, M; Smith, MD; Osterloh, I;
Indirizzi:
Univ Lund Hosp, Dept Urol, S-22185 Lund, Sweden Univ Lund Hosp Lund Sweden S-22185 Hosp, Dept Urol, S-22185 Lund, Sweden
Titolo Testata:
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
fascicolo: 9, volume: 54, anno: 2000,
pagine: 561 - 566
SICI:
1368-5031(200011)54:9<561:SC((IE>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
ORAL SILDENAFIL; DOUBLE-BLIND; IMPOTENCE; THERAPY; MANAGEMENT; SAFETY; PHYSIOLOGY; INJECTION; YOHIMBINE; ETIOLOGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Olsson, AM Univ Lund Hosp, Dept Urol, S-22185 Lund, Sweden Univ Lund HospLund Sweden S-22185 Urol, S-22185 Lund, Sweden
Citazione:
A.M. Olsson et al., "Sildenafil citrate (Viagra (R)) is effective and well tolerated for treating erectile dysfunction of psychogenic or mixed aetiology", INT J CL PR, 54(9), 2000, pp. 561-566

Abstract

Sildenafil citrate (Viagra(R)) has been shown to be an effective treatmentfor erectile dysfunction (ED) of organic aetiology. This study assessed the efficacy and tolerability of sildenafil for treating ED of psychogenic and mixed psychogenic/organic aetiology. Men with ED of psychogenic and mixedaetiology were randomised in a double-blind, fixed-dose study to placebo (n=95) or sildenafil 10 mg (n=90), 25 mg (n=85), or 50 mg (n=81) once daily for 28 days. Efficacy was evaluated with two global efficacy questions, a patient log of erectile activity, a sexual function questionnaire and a partner questionnaire. Patients receiving sildenafil had significantly more grade 3 (hard enough for penetration) or grade 4 (fully hard) erections per week than patients receiving placebo, and a greater proportion of patients receiving sildenafil reported that treatment had improved their erections (p<0.001). Results of the sexual function questionnaire demonstrated significant improvement for patients with ED receiving sildenafil compared with patients receiving placebo for frequency, hardness and duration of erections (p<0,01), and for enjoyment of sexual intercourse and satisfaction with sex life (p<0,05), The results of the partner questionnaire were consistent withthe results reported by patients and showed that treatment with sildenafilwas associated with significant improvement in the partners' own sex lives(p<0.001). Adverse events were mostly mild to moderate in nature. The commonest adverse events were headache, dyspepsia, flushing, myalgia, arthralgia and flu syndrome. Discontinuations due to treatment-related adverse events were few, ranging from 1.1% to 6.2% for patients receiving different doses of sildenafil and 4.2% for patients receiving placebo. Sildenafil is an effective and well-tolerated treatment for ED of psychogenic or mixed aetiology with once-daily dosing.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 16:12:52