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Titolo:
Synthesis, conformation and vibrational dynamics of apolipoprotein B fragment, -Asn-Cys-Lys-Val-Glu-Leu-
Autore:
Srivastava, S; Melkani, GC; Singh, S; Gupta, VD;
Indirizzi:
Cent Drug Res Inst, Div Biopolymers, Lucknow 226001, Uttar Pradesh, India Cent Drug Res Inst Lucknow Uttar Pradesh India 226001 ttar Pradesh, India
Titolo Testata:
INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS
fascicolo: 5, volume: 37, anno: 2000,
pagine: 318 - 333
SICI:
0301-1208(200010)37:5<318:SCAVDO>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMINO-ACID SEQUENCE; HEAT-CAPACITY; COMPLETE CDNA; SPECTROSCOPY; B-100;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Gupta, VD Cent Drug Res Inst, Div Biopolymers, Lucknow 226001, Uttar Pradesh, India Cent Drug Res Inst Lucknow Uttar Pradesh India 226001 sh, India
Citazione:
S. Srivastava et al., "Synthesis, conformation and vibrational dynamics of apolipoprotein B fragment, -Asn-Cys-Lys-Val-Glu-Leu-", I J BIOCH B, 37(5), 2000, pp. 318-333

Abstract

It is assumed that all biological processes are dynamical in nature and the low frequency collective modes, particularly the skeletal modes arising from the main chain and the side chain play an important role in such processes. To identify these a complete normal mode analysis of the hexapeptide -Asn-Cys-Lys-Val-Glu-Leu-, a fragment of apolipoprotein B has been carried out. The assignment of modes is greatly assisted by similar studies on the tetra -Cys-Lys-Val-Glu- and tripeptides (-Asn-Cys-Lys-, -Val-Glu-Leu-) fragments of the hexapeptide. All the four peptides have been synthesized by thesolid phase peptide method using 9-flurrenyl methyloxycarbonyl (Fmoc) on 4-methyl benzhyldrylamine (MBHA) and Wang's resins. Their conformation is determined from the Ramachandran Maps which are based on the global energy minimization method. It is supported by the propensity parameters for the amino acids.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 21:39:39