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Titolo:
Hypertension and its treatment in postmenopausal women - Baseline data from the Women's Health Initiative
Autore:
Wassertheil-Smoller, S; Anderson, G; Psaty, BM; Black, HR; Manson, J; Wong, N; Francis, J; Grimm, R; Kotchen, T; Langer, R; Lasser, N;
Indirizzi:
Albert Einstein Coll Med, Dept Epidemiol & Social Med, Bronx, NY 10461 USAAlbert Einstein Coll Med Bronx NY USA 10461 cial Med, Bronx, NY 10461 USA Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA Fred Hutchinson Canc Res Ctr Seattle WA USA 98104 , Seattle, WA 98104 USA Univ Washington, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 iv Washington, Seattle, WA 98195 USA Rush Presbyterian St Lukes Med Ctr, Chicago, IL 60612 USA Rush Presbyterian St Lukes Med Ctr Chicago IL USA 60612 ago, IL 60612 USA Harvard Univ, Brigham & Womens Hosp, Sch Med, Boston, MA 02115 USA HarvardUniv Boston MA USA 02115 mens Hosp, Sch Med, Boston, MA 02115 USA Univ Calif Irvine, Heart Dis Prevent Program, Irvine, CA 92717 USA Univ Calif Irvine Irvine CA USA 92717 event Program, Irvine, CA 92717 USA Univ Minnesota, Sch Med, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 ch Med, Minneapolis, MN 55455 USA Med Coll Wisconsin, Milwaukee, WI 53226 USA Med Coll Wisconsin Milwaukee WI USA 53226 consin, Milwaukee, WI 53226 USA Univ Calif San Diego, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 Diego, La Jolla, CA 92093 USA Univ Med & Dent New Jersey, Newark, NJ 07103 USA Univ Med & Dent New Jersey Newark NJ USA 07103 rsey, Newark, NJ 07103 USA
Titolo Testata:
HYPERTENSION
fascicolo: 5, volume: 36, anno: 2000,
pagine: 780 - 789
SICI:
0194-911X(200011)36:5<780:HAITIP>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIOVASCULAR EVENTS; POPULATION; PREVALENCE; OUTCOMES; TRENDS; RISK; METAANALYSIS; MORTALITY; THERAPIES;
Keywords:
hypertension, essential; age; antihypertensive agents; blood pressure; women; Women's Health Initiative (WHI);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Wassertheil-Smoller, S Albert Einstein Coll Med, Dept Epidemiol & Social Med, 1300 Morris Pk Ave,Room 1312 Belfer, Bronx, NY 10461 USA Albert Einstein Coll Med 1300 Morris Pk Ave,Room 1312 Belfer Bronx NY USA 10461
Citazione:
S. Wassertheil-Smoller et al., "Hypertension and its treatment in postmenopausal women - Baseline data from the Women's Health Initiative", HYPERTENSIO, 36(5), 2000, pp. 780-789

Abstract

Little is known about the patterns of treatment and adequacy of blood pressure control in older women. The Women's Health Initiative, a 40-center national study of risk factors and prevention of heart disease, breast and colorectal cancer, and osteoporosis in postmenopausal women, provides a uniqueopportunity to examine these issues in the largest, multiethnic, best-characterized such cohort. Baseline data from the initial 98 705 women, aged 50to 79 years, enrolled were analyzed to relate prevalence, treatment, and control of hypertension to demographic, clinical, and risk-factor covariates, and logistic regression analyses were performed to estimate odds ratios after adjusting for multiple potential confounders. Overall, 37.8% of the women had hypertension, which is defined as systolic blood pressure greater than or equal to 140 mm Hg and/or diastolic blood pressure greater than or equal to 90 mm Hg or being on medication for high blood pressure; 64.3% weretreated with drugs, and blood pressure was controlled in only 36.1% of thehypertensive women, with lower rates of control in the oldest group. Afteradjustment for multiple covariates, current hormone users had higher prevalence than did nonusers (odds ratio 1.25). Hypertensive women had more comorbid conditions than did nonhypertensive women, and women with comorbidities were more likely to be treated pharmacologically. Diuretics were used by 44.3% of hypertensives either as monotherapy or in combination with other drug classes. As monotherapy, calcium channel blockers were used in 16%, angiotensin-converting enzyme inhibitors in 14%, beta -blockers in 9%, and diuretics in 14% of the hypertensive women. Diuretics as monotherapy were associated with better blood pressure control than any of the other drug classes as monotherapy. In conclusion, hypertension in older women is not being treated aggressively enough because a large proportion, especially those most at risk for stroke and heart disease by virtue of age, does not have-sufficient blood pressure control.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 05:55:40