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Titolo:
Zebrafish nma is involved in TGF beta family signaling
Autore:
Tsang, M; Kim, R; de Caestecker, MP; Kudoh, T; Roberts, AB; Dawid, IB;
Indirizzi:
NICHHD, Mol Genet Lab, Bethesda, MD 20892 USA NICHHD Bethesda MD USA 20892 ICHHD, Mol Genet Lab, Bethesda, MD 20892 USA NCI, Lab Cell Regulat & Carcinogenesis, NIH, Bethesda, MD 20892 USA NCI Bethesda MD USA 20892 t & Carcinogenesis, NIH, Bethesda, MD 20892 USA
Titolo Testata:
GENESIS
fascicolo: 2, volume: 28, anno: 2000,
pagine: 47 - 57
SICI:
1526-954X(200010)28:2<47:ZNIIIT>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
DORSOVENTRAL PATTERN-FORMATION; GROWTH-FACTOR-BETA; ONE-EYED PINHEAD; XENOPUS-EMBRYOS; SPEMANN ORGANIZER; HOMEOBOX GENE; MESODERM; EXPRESSION; PROTEIN; ANTAGONIST;
Keywords:
nma; Bambi; BMP; patterning; development;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Dawid, IB NICHHD, Mol Genet Lab, Bldg 6B-420, Bethesda, MD 20892 USA NICHHD Bldg 6B-420 Bethesda MD USA 20892 Bethesda, MD 20892 USA
Citazione:
M. Tsang et al., "Zebrafish nma is involved in TGF beta family signaling", GENESIS, 28(2), 2000, pp. 47-57

Abstract

Bone morphogenetic proteins (BMP) are members of the TGF beta superfamily of secreted factors with important regulatory functions during embryogenesis, We have isolated the zebrafish gene, nma, that encodes a protein with high sequence similarity to human NMA and Xenopus Bambi, It is also similar to TGF beta type I serine/theronine kinase receptors in the extracellular ligand-binding domain but lacks a cytoplasmic kinase domain. During development, nma expression is similar to that of bmp2b and bmp4, and analysis in the dorsalized and ventralized zebrafish mutants swirl and chordino indicatesthat nma is regulated by BMP signaling. Overexpression of nma during zebrafish and Xenopus development resulted in phenotypes that appear to be basedon inhibition of BMP signaling. Biochemically, NMA can associate with TGF beta type II receptors and bind to TGF beta ligand. We propose that nma is a BMP-regulated gene whose function is to attenuate BMP signaling during development through interactions with type II receptors and ligands. Published 2000 Wiley-Liss, Inc.(dagger)

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:23:19