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Titolo:
Changes in serum levels of quinolones in rats under the influence of experimental trauma
Autore:
Trichilis, A; Tesserommatis, C; Varonos, D;
Indirizzi:
Univ Athens, Sch Med, Dept Pharmacol, Athens 11527, Greece Univ Athens Athens Greece 11527 ed, Dept Pharmacol, Athens 11527, Greece
Titolo Testata:
EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS
fascicolo: 2, volume: 25, anno: 2000,
pagine: 73 - 78
SICI:
0378-7966(200004/06)25:2<73:CISLOQ>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPATIC DRUG-METABOLISM; PLASMA-PROTEIN BINDING; INJURY; STRESS; EXCRETION;
Keywords:
quinolones; trauma; FFA; serum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Tesserommatis, C Univ Athens, Sch Med, Dept Pharmacol, M Asias 75, Athens 11527, Greece Univ Athens M Asias 75 Athens Greece 11527 11527, Greece
Citazione:
A. Trichilis et al., "Changes in serum levels of quinolones in rats under the influence of experimental trauma", EUR J DRUG, 25(2), 2000, pp. 73-78

Abstract

Administration of antibiotics is considered an important factor during, orafter, operational procedures in the maxillofacial area, in order to avoidpost-surgical complications. In the present study, the levels of quinolones in serum and tissues such as the parotid gland, the tongue and the bone of the jaws were estimated during traumatic injury in the oral cavity. For this purpose, two groups (A and B) of Wistar rats, consisting of 35 animals each were used. Group A (control) and group B (experimental) were divided in five subgroups (A(1), A(2), A(3), A(4), A(5) and B-1, B-2, B-3, B-4, B-5). In the experimental group, model traumatic injury was performed through the whole length of the cheek. Subjects received orally ciprofloxacin, pefloxacin, norfloxacin, ofloxacin and cinoxacin. The concentration of quinolones in serum and in most of the tissues was significantly higher in the experimental groups than in controls. In addition, the FFA levels and the weightof adrenals (as indicators of stress) were higher in the trauma groups. Stress seemed to affect many pathophysiological mechanisms which are responsible for the alterations observed.

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Documento generato il 01/04/20 alle ore 11:43:24