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Titolo:
Involvement of muscarinic cholinergic and alpha(2)-adrenergic mechanisms in growth hormone secretion during exercise in humans
Autore:
Harada, T; Yamauchi, T; Tsukanaka, A; Matsumura, Y; Kurono, M; Honda, A; Matsui, N;
Indirizzi:
Chukyo Univ, Exercise Physiol Lab, Toyota, Aichi 4700348, Japan Chukyo Univ Toyota Aichi Japan 4700348 Lab, Toyota, Aichi 4700348, Japan Ishinomaki Senshu Univ, Sch Sci & Engn, Div Basic Sci, Ishinomaki, Miyagi 9868580, Japan Ishinomaki Senshu Univ Ishinomaki Miyagi Japan 9868580 agi 9868580, Japan
Titolo Testata:
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 4-5, volume: 83, anno: 2000,
pagine: 268 - 273
SICI:
1439-6319(200011)83:4-5<268:IOMCAA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED GH SECRETION; (GH)-RELEASING HORMONE; GLUCOCORTICOID THERAPY; RELEASE; CLONIDINE; SOMATOSTATIN; PYRIDOSTIGMINE; MEDIATION; TONE; PIRENZEPINE;
Keywords:
atropine; yohimbine; growth hormone; exercise; humans;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Harada, T Chukyo Univ, Exercise Physiol Lab, 101 Tokodachi, Toyota, Aichi 4700348, Japan Chukyo Univ 101 Tokodachi Toyota Aichi Japan 4700348 0348, Japan
Citazione:
T. Harada et al., "Involvement of muscarinic cholinergic and alpha(2)-adrenergic mechanisms in growth hormone secretion during exercise in humans", EUR J A PHY, 83(4-5), 2000, pp. 268-273

Abstract

The purpose of this study was to examine the rule of muscarinic cholinergic and alpha (2)-adrenergic mechanisms in growth hormone (GH) secretion during exercise in humans. The GH responses induced during moderate-intensity exercise (using a cycle ergometer at 60% maximal oxygen uptake, (V) over dotO-2max. for 30 min) without treatment (control) and after the administration of a muscarinic cholinergic antagonist (atropine 1 mg) or after an alpha(2)-adrenergic antagonist (yohimbine 15 mg) were compared in seven healthymen. Although, serum GH concentration had increased significantly after exercise in the control experiment [mean peal; GH concentration 52.64 (SEM 18.60) ng . ml(-1)], the increase was suppressed by the administration of either atropine [mean peak GH concentration 8.64 (SEM 7.47) ng . ml(-1)] or yohimbine [mean peak GH concentration 17.50 (SEM 7.89) ng . ml(-1)]. The areaunder the curve of serum GH concentration against time was significantly lower in the experiment using these drugs [with atropine, mean area 458 (SEM409) ng . ml(-1) . min], with yohimbine mean area 946 (SEM 435) ng . ml(-1) . min] than in the control experiment [mean area 3135 (SEM 1098) ng . ml(-1) . min]. These results suggest that muscarinic cholinergic and alpha (2)-adrenergic mechanisms are involved in GH secretion during exercise in humans.

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Documento generato il 23/01/20 alle ore 18:40:50