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Titolo:
Evidence for surfactant contributing to the gastric mucosal barrier of thehorse
Autore:
Ethell, MT; Hodgson, DR; Hills, BA;
Indirizzi:
Univ Sydney, Univ Vet Ctr, Camden, NSW, Australia Univ Sydney Camden NSW Australia y, Univ Vet Ctr, Camden, NSW, Australia Univ Queensland, Mater Childrens Hosp, Paediat Resp Res Ctr, Brisbane, Qld4101, Australia Univ Queensland Brisbane Qld Australia 4101 Brisbane, Qld4101, Australia
Titolo Testata:
EQUINE VETERINARY JOURNAL
fascicolo: 6, volume: 32, anno: 2000,
pagine: 470 - 474
SICI:
0425-1644(200011)32:6<470:EFSCTT>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
HELICOBACTER-PYLORI; HYDROPHOBICITY; ASPIRIN; PHOSPHATIDYLCHOLINE; PROSTAGLANDIN-E2; PROTECTION; ULCERATION; EPITHELIUM; STOMACH; DRUGS;
Keywords:
horse; gastric mucosal barrier; surface-active phospholipid; gastric surfactant; hydrophobic barrier;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Hodgson, DR Univ Sydney, Univ Vet Ctr, Camden, NSW, Australia Univ SydneyCamden NSW Australia Ctr, Camden, NSW, Australia
Citazione:
M.T. Ethell et al., "Evidence for surfactant contributing to the gastric mucosal barrier of thehorse", EQUINE V J, 32(6), 2000, pp. 470-474

Abstract

This study was undertaken to determine the hydrophobicity of the luminal surface of the equine stomach and to elucidate the ultrastructure of the lining imparting that property. Gastric and duodenal mucosal samples from 5 horses were collected immediately after euthanasia and subjected to surface contact angle measurement using a goniometer. Gastric mucosal samples from 4horses and a foal were examined by electron microscopy following a fixation procedure known to preserve phospholipids and oligolamellar structures. Contact angles for the equine gastric glandular mucosal surface (mean +/- s.e. 78.0 +/- 11.0 degrees) were greater than for the duodenum (33.4 +/- 8.7 degrees), (P = 0.003). The contact angles for gastric squamous tissue (50.4+/- 4.5 degrees) tended to be greater than for duodenum (P = 0.15). Electron microscopy revealed the existence of surfactant as abundant osmiophilic phospholipid material within both squamous and glandular gastric mucosae. These results indicate the hydrophobic nature of the equine gastric mucosae. We propose that the water-repellent nature of the stomach contributes to the 'gastric mucosal barrier' and is imparted by surface-active phospholipidadsorbed to the surface. Phospholipids may also be utilised as a physical barrier to back-diffusion of acid by Lining intracellular canaliculi and oxyntic ducts where other defence mechanisms are absent.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 08:55:17