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Titolo:
Monozygotic boys with fragile X syndrome
Autore:
Sheldon, L; Turk, J;
Indirizzi:
St Georges Hosp, SW London & St Georges Mental Hlth NHS Trust, London SW170QT, England St Georges Hosp London England SW17 0QT S Trust, London SW170QT, England St Georges Hosp, Sch Med, London SW17 0QT, England St Georges Hosp London England SW17 0QT ch Med, London SW17 0QT, England
Titolo Testata:
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
fascicolo: 11, volume: 42, anno: 2000,
pagine: 768 - 774
SICI:
0012-1622(200011)42:11<768:MBWFXS>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
IDENTICAL-TWINS; POSTERIOR-FOSSA; FULL MUTATION; FOLIC-ACID; AUTISM; NEUROANATOMY; CHILDREN; FEMALES; INDIVIDUALS; RECOGNITION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Sheldon, L St Georges Hosp, SW London & St Georges Mental Hlth NHS Trust, Clare House,Blackshaw Rd, London SW17 0QT, England St Georges Hosp Clare House,Blackshaw Rd London England SW17 0QT
Citazione:
L. Sheldon e J. Turk, "Monozygotic boys with fragile X syndrome", DEVELOP MED, 42(11), 2000, pp. 768-774

Abstract

Monozygotic twin boys with fragile X syndrome underwent thorough genetic, psychiatric, neurological, and language evaluations at 10 years of age. They both demonstrated physical features, speech and language difficulties, social problems, and attentional deficits that characterize the behavioural phenotype of fragile X syndrome. Despite identical genetic constitutions, there were important developmental and behavioural heterogeneities. Twin A showed less social interaction and symbolic play and more speech and languagedysfunction than twin B. Twin A also had significantly larger caudate volumes. It is suggested that the Xq27.3 anomaly may not be sufficient to account for all the behavioural phenotypic and neuroanatomical features of fragile X syndrome.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 02:49:17