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Titolo:
Serum NGF levels in children and adolescents with either Williams syndromeor Down syndrome
Autore:
Calamandrei, G; Alleva, E; Cirulli, F; Queyras, A; Volterra, V; Capirci, O; Vicari, S; Giannotti, A; Turrini, P; Aloe, L;
Indirizzi:
CNR, Inst Neurobiol, I-00137 Rome, Italy CNR Rome Italy I-00137CNR, Inst Neurobiol, I-00137 Rome, Italy Ist Super Sanita, Lab Fisiopatol Organo & Sistema, I-00161 Rome, Italy IstSuper Sanita Rome Italy I-00161 rgano & Sistema, I-00161 Rome, Italy CNR, Inst Psychol, I-00137 Rome, Italy CNR Rome Italy I-00137CNR, Inst Psychol, I-00137 Rome, Italy Childrens Hosp Bambino Gesu, IRCCS, Santa Marinella, Italy Childrens Hosp Bambino Gesu Santa Marinella Italy anta Marinella, Italy Childrens Hosp Bambino Gesu, IRCCS, Rome, Italy Childrens Hosp Bambino Gesu Rome Italy Bambino Gesu, IRCCS, Rome, Italy
Titolo Testata:
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
fascicolo: 11, volume: 42, anno: 2000,
pagine: 746 - 750
SICI:
0012-1622(200011)42:11<746:SNLICA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE-GROWTH-FACTOR; CEREBROSPINAL-FLUID; RETT-SYNDROME; ABILITIES; HEMIZYGOSITY; ANTIBODIES; MECHANISMS; COGNITION; BRAIN; TASK;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Vicari, S CNR, Inst Neurobiol, Viale C Marx 15, I-00137 Rome, Italy CNR Viale C Marx 15 Rome Italy I-00137 15, I-00137 Rome, Italy
Citazione:
G. Calamandrei et al., "Serum NGF levels in children and adolescents with either Williams syndromeor Down syndrome", DEVELOP MED, 42(11), 2000, pp. 746-750

Abstract

The neurotrophin nerve growth factor (NGF) is a major regulator of peripheral and central nervous system development. Serum NGF was measured in normally developing control children (n=26) and in individuals affected by congenital syndromes associated with learning disability: either Williams syndrome (WS; n=12) or Down syndrome (DS; n=21). Participants were assessed at three distinct developmental stages: early childhood (2 to 6 years), childhood (8 to 12 years),and adolescence (14 to 20 years). A sample was taken onlyonce from each individual. Serum NGF levels were markedly higher in Participants with WS, than DS and control participants. In addition, different developmental profiles emerged in the three groups: while in normally developing individuals NGF levels were higher in early childhood than later on, children with WS showed constantly elevated NGF levels. When compared to control participants, those with DS showed lower NGF levels only during early childhood. Neuropsychological assessment confirmed previously reported differences among the three groups in the development of linguistic/cognitive abilities. Some features of individuals with WS, such as hyperacusis and hypertension, could be related to high-circulating NGF levels.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 07:21:23