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Titolo:
Glypican-4 is an FGF2-binding heparan sulfate proteoglycan expressed in neural precursor cells
Autore:
Hagihara, K; Watanabe, K; Chun, J; Yamaguchi, Y;
Indirizzi:
Burnham Inst, La Jolla, CA 92037 USA Burnham Inst La Jolla CA USA 92037Burnham Inst, La Jolla, CA 92037 USA Univ Calif San Diego, Sch Med, Dept Pharmacol, La Jolla, CA 92093 USA UnivCalif San Diego La Jolla CA USA 92093 rmacol, La Jolla, CA 92093 USA Univ Calif San Diego, Sch Med, Grad Program Neurosci, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 urosci, La Jolla, CA 92093 USA
Titolo Testata:
DEVELOPMENTAL DYNAMICS
fascicolo: 3, volume: 219, anno: 2000,
pagine: 353 - 367
SICI:
1058-8388(200011)219:3<353:GIAFHS>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIBROBLAST GROWTH-FACTOR; CENTRAL-NERVOUS-SYSTEM; DEVELOPING CEREBRAL-CORTEX; DEVELOPING RAT-BRAIN; CNS STEM-CELLS; LYSOPHOSPHATIDIC ACID; PROGENITOR CELLS; MOUSE-BRAIN; SURFACE PROTEOGLYCAN; CHONDROITIN SULFATE;
Keywords:
heparan sulfate proteoglycan; glypican-4; K-glypican; FGF2; neural stem cells; cortical neurogenesis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
71
Recensione:
Indirizzi per estratti:
Indirizzo: Yamaguchi, Y Burnham Inst, 10904 N Torrey Pines Rd, La Jolla, CA 92037 USABurnham Inst 10904 N Torrey Pines Rd La Jolla CA USA 92037 SA
Citazione:
K. Hagihara et al., "Glypican-4 is an FGF2-binding heparan sulfate proteoglycan expressed in neural precursor cells", DEV DYNAM, 219(3), 2000, pp. 353-367

Abstract

FGF2 is a crucial mitogen for neural precursor cells in the developing cerebral cortex. Heparan sulfate proteoglycans (HSPGs) are thought to play a role in cortical neurogenesis by regulating the action of FGF2 on neural precursor cells. In this article, we present data indicating that glypican-4 (K-glypican), a GPI-anchored cell surface HSPG, is involved in these processes. In the developing mouse brain, glypican-4 mRNA is expressed predominantly in the ventricular zone of the telencephalon, Neither the outer layers of the telencephalic wall nor the ventricular zone of other parts of the developing brain express significant levels of glypican-4, with the exception of the ventricular zone of the tectum. In cultures of E13 rat cortical precursor cells, glypican-4 is expressed in cells immunoreactive for nestin andthe D1.1 antigen, markers of neural precursor cells. Glypican-4 expressionwas not detected in early postmitotic or fully differentiated neurons. Recombinant glypican-4 produced in immortalized neural precursor cells binds FGF2 through its heparan sulfate chains and suppressed the mitogenic effect of FGF2 on E13 cortical precursor cells. The spatiotemporal expression pattern of glypican-4 in the developing cerebral wall significantly overlaps with that of FGF2, These results suggest that glypican-4 plays a critical role in the regulation of FGF2 action during cortical neurogenesis, (C) 2000 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 08:50:30