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Titolo:
Cardiac allograft vasculopathy
Autore:
Behrendt, D; Ganz, P; Fang, JC;
Indirizzi:
Harvard Univ, Brigham & Womens Hosp, Div Cardiovasc, Sch Med, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 ardiovasc, Sch Med, Boston, MA 02115 USA
Titolo Testata:
CURRENT OPINION IN CARDIOLOGY
fascicolo: 6, volume: 15, anno: 2000,
pagine: 422 - 429
SICI:
0268-4705(200011)15:6<422:CAV>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; HEART-TRANSPLANT RECIPIENTS; DOBUTAMINE STRESS ECHOCARDIOGRAPHY; INTRAVASCULAR ULTRASOUND; ENDOTHELIAL DYSFUNCTION; INTRACORONARY ULTRASOUND; CYTOMEGALOVIRUS-INFECTION; IMMUNOSUPPRESSIVE THERAPY; NONINVASIVE ASSESSMENT; VASCULAR ENDOTHELIUM;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
100
Recensione:
Indirizzi per estratti:
Indirizzo: Fang, JC Harvard Univ, Brigham & Womens Hosp, Div Cardiovasc, Sch Med, 75 Francis St, Boston, MA 02115 USA Harvard Univ 75 Francis St Boston MA USA 02115 ston, MA 02115 USA
Citazione:
D. Behrendt et al., "Cardiac allograft vasculopathy", CURR OPIN C, 15(6), 2000, pp. 422-429

Abstract

Cardiac transplantation has emerged as a valuable therapy for various end-stage cardiac disorders. Cardiac allograft vasculopathy (CAV), an unusuallyaccelerated and diffuse form of obliterative coronary arteriosclerosis, determines long-term function of the transplanted heart. Cardiac allograft vasculopathy is a complicated interplay between immunologic and nonimmunologic factors resulting in repetitive vascular injury and a localized sustainedinflammatory response. Dyslipidemia, oxidant stress, immunosuppressive drugs, and viral infection appear to be important contributors to disease development. Endothelial dysfunction is an early feature of CAV and progresses over time after transplantation Early identification of CAV is essential iflong-term prognosis is to be improved. Annual coronary angiography is performed for diagnostic and surveillance purposes. Intravascular ultrasound isa more sensitive diagnostic fool for early disease stages and has revealedthat progressive luminal narrowing in CAV is in part due to negative vascular remodeling. Because of the diffuse nature of CAV, percutaneous and surgical revascularization procedures have a limited rate. Prevention of CAV progression is a primary therapeutic goal. (C) 1000 Lippincott Williams & Wilkins, Inc.

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Documento generato il 10/04/20 alle ore 02:41:06