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Titolo:
Resistant herpes simplex virus type 1 infection: An emerging concern afterallogeneic stem cell transplantation
Autore:
Chen, Y; Scieux, C; Garrait, V; Socie, G; Rocha, V; Molina, JM; Thouvenot, D; Morfin, F; Hocqueloux, L; Garderet, L; Esperou, H; Selimi, F; Devergie, A; Leleu, G; Aymard, M; Morinet, F; Gluckman, E; Ribaud, P;
Indirizzi:
Hop St Louis, Serv Hematol Greffe de Moelle, F-75475 Paris 10, France Hop St Louis Paris France 10 Greffe de Moelle, F-75475 Paris 10, France Hop St Louis, Virol Lab, F-75475 Paris, France Hop St Louis Paris FranceF-75475 ouis, Virol Lab, F-75475 Paris, France Hop St Louis, Serv Malad Infect, F-75475 Paris 10, France Hop St Louis Paris France 10 Serv Malad Infect, F-75475 Paris 10, France Hop St Louis, Serv Reanimat Med, F-75475 Paris 10, France Hop St Louis Paris France 10 Serv Reanimat Med, F-75475 Paris 10, France Hospices Civils Lyon, Virol Lab, Lyon, France Hospices Civils Lyon Lyon France s Civils Lyon, Virol Lab, Lyon, France
Titolo Testata:
CLINICAL INFECTIOUS DISEASES
fascicolo: 4, volume: 31, anno: 2000,
pagine: 927 - 935
SICI:
1058-4838(200010)31:4<927:RHSVT1>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MARROW TRANSPLANTATION; SUCCESSFUL FOSCARNET THERAPY; ACYCLOVIR-RESISTANT; MUCOCUTANEOUS INFECTION; DNA-POLYMERASE; ANTIVIRAL DRUGS; RECIPIENTS; AIDS; CIDOFOVIR; PATIENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Ribaud, P Hop St Louis, Serv Hematol Greffe de Moelle, 1 Ave Claude Vellefaux, F-75475 Paris 10, France Hop St Louis 1 Ave Claude Vellefaux Paris France 10 10, France
Citazione:
Y. Chen et al., "Resistant herpes simplex virus type 1 infection: An emerging concern afterallogeneic stem cell transplantation", CLIN INF D, 31(4), 2000, pp. 927-935

Abstract

Fourteen cases of severe acyclovir-resistant herpes simplex virus type I (HSV-1) infection, 7 of which showed resistance to foscarnet, were diagnosedamong 196 allogeneic stem cell transplant recipients within a 29-month period. Recipients of unrelated stem cell transplants were at higher risk. Allpatients received foscarnet; 8 subsequently received cidofovir, Strains were initially foscarnet-resistant in 3 patients and secondarily so in 4 patients. In vitro resistance to acyclovir or foscarnet was associated with clinical failure of these drugs; however, in vitro susceptibility to foscarnetwas associated with complete response in only 5 of 7 patients. No strain from any of the 7 patients was resistant in vitro to cidofovir; however, only 3 of 7 patients achieved complete response. Therefore, acyclovir- and/or foscarnet-resistant HSV-1 infections after allogeneic stem cell transplantation have become a concern; current strategies need to be reassessed and new strategies must be evaluated in this setting.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 13:59:17