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Titolo:
Effects of DHEA replacement on bone mineral density and body composition in elderly women and men
Autore:
Villareal, DT; Holloszy, JO; Kohrt, WM;
Indirizzi:
Washington Univ, Sch Med,Claude Pepper Older Amer Independence Ctr, Dept Internal Med, Div Geriatr & Gerontol, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 & Gerontol, St Louis, MO 63110 USA
Titolo Testata:
CLINICAL ENDOCRINOLOGY
fascicolo: 5, volume: 53, anno: 2000,
pagine: 561 - 568
SICI:
0300-0664(200011)53:5<561:EODROB>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTMENOPAUSAL WOMEN; DEHYDROEPIANDROSTERONE REPLACEMENT; ORAL DEHYDROEPIANDROSTERONE; THERAPY; SERUM; LIPOPROTEIN; INCREASES; FAT; AGE; METABOLISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Kohrt, WM Univ Colorado, Hlth Sci Ctr, Dept Geriatr Med, 4200 E 9th Ave,Campus Box B-179, Denver, CO 80262 USA Univ Colorado 4200 E 9th Ave,Campus Box B-179 Denver CO USA 80262
Citazione:
D.T. Villareal et al., "Effects of DHEA replacement on bone mineral density and body composition in elderly women and men", CLIN ENDOCR, 53(5), 2000, pp. 561-568

Abstract

OBJECTIVE Dehydroepiandrosterone (DHEA) is a precursor for both oestrogensand androgens. Its marked decline with ageing may influence age-related changes in tissues influenced by sex hormones. The aim of this study was to determine the effects of DHEA replacement on bone mineral density (BMD) and body composition in elderly women and men with low serum DHEA sulphate (DHEAS) levels. DESIGN Prospective 6 month trial of oral DHEA replacement, 50 mg/day. PATIENTS Experimental subjects were 10 women and eight men, aged 73 +/- 1 years. Control subjects were 10 women and eight men, aged 74 +/- 1 years. MEASUREMENTS BMD, body composition, serum markers of bone turnover, serum lipids and lipoproteins, oral glucose tolerance, serum IGF-I, total serum oestrogens and testosterone. RESULTS BMD of the total body and lumbar spine increased (mean +/- SEM; 1.6 +/- 0.6% and 2.5 +/- 0.8%, respectively; both P less than or equal to 0.05), fat mass decreased (- 1.3 +/- 0.4 kg; P < 0.01) and fat-free mass increased (0.9 +/- 0.4 kg; P less than or equal to 0.05) in response to DHEA replacement. DHEA replacement also resulted in increases in serum IGF-I (from 108 +/- 8 to 143 +/- 7 mug/l; P < 0.01) and total serum testosterone concentrations (from 10.7 +/- 1.2 to 15.6 +/- 1.8 nmol/l in the men and from 2.1 /- 0.2 to 4.5 +/- 0.4 nmol/l in the women; both P less than or equal to 0.05). CONCLUSIONS The results provide preliminary evidence that DHEA replacementin those elderly women and men who have very low serum DHEAS levels can partially reverse age-related changes in fat mass, fat-free mass, and BMD, and raise the possibility that increases in IGF-I and/or testosterone play a role in mediating these effects of DHEA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 22:35:24