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Titolo:
Apoptosis during cardiovascular development
Autore:
Fisher, SA; Langille, BL; Srivastava, D;
Indirizzi:
Univ Toronto, Hlth Network, Toronto Gen Hosp, Toronto, ON M5G 2C4, Canada Univ Toronto Toronto ON Canada M5G 2C4 Hosp, Toronto, ON M5G 2C4, Canada Case Western Reserve Univ, Sch Med, Dept Med, Cleveland, OH 44106 USA CaseWestern Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA Case Western Reserve Univ, Sch Med, Dept Physiol, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada Univ Toronto Toronto ON Canada Lab Med & Pathobiol, Toronto, ON, Canada Univ Texas, SW Med Ctr, Dept Pediat Cardiol, Dallas, TX 75230 USA Univ Texas Dallas TX USA 75230 Dept Pediat Cardiol, Dallas, TX 75230 USA Univ Texas, SW Med Ctr, Dept Mol Biol, Dallas, TX 75230 USA Univ Texas Dallas TX USA 75230 d Ctr, Dept Mol Biol, Dallas, TX 75230 USA
Titolo Testata:
CIRCULATION RESEARCH
fascicolo: 10, volume: 87, anno: 2000,
pagine: 856 - 864
SICI:
0009-7330(20001110)87:10<856:ADCD>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRAMMED CELL-DEATH; NITRIC-OXIDE SYNTHASE; RIGHT-VENTRICULAR DYSPLASIA; VASCULAR SMOOTH-MUSCLE; CARDIAC CONDUCTION SYSTEM; RECEPTOR TYROSINE KINASES; CHICK-EMBRYO HEART; NEURAL CREST CELLS; ENDOTHELIAL-CELLS; OUTFLOW TRACT;
Keywords:
apoptosis; development; myocardium; smooth muscle; endothelium;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
126
Recensione:
Indirizzi per estratti:
Indirizzo: Langille, BL Univ Toronto, Hlth Network, Toronto Gen Hosp, 200 Elizabeth St,CCRW 1-836,Toronto, ON M5G 2C4, Canada Univ Toronto 200 Elizabeth St,CCRW1-836 Toronto ON Canada M5G 2C4
Citazione:
S.A. Fisher et al., "Apoptosis during cardiovascular development", CIRCUL RES, 87(10), 2000, pp. 856-864

Abstract

Morphogenesis and developmental remodeling of cardiovascular tissues involve coordinated regulation of cell proliferation and apoptosis. In the heart, clear evidence points toward focal apoptosis as a contributor to development of the embryonic outflow tract, cardiac valves, conducting system, and the developing coronary vasculature. Apoptosis in the heart is likely regulated by survival and death signals that are also present in many other tissues. Cell type-specific regulation may be superimposed on general cell death/survival machinery through tissue-specific transcriptional pathways. In the vasculature, apoptosis almost certainly contributes to developmental vessel regression, and it is of proven importance in remodeling of arterial structure in response to local changes in hemodynamics, Physical forces, growth factors, and extracellular matrix drive vascular cell survival pathways,and considerable evidence points to local nitric oxide production as an important but complex regulator of vascular cell death. In both the heart andvasculature, progress has been impeded by inadequate information concerning the incidence of apoptosis, its relative importance compared with the diverse cell behaviors that remodel developing tissues, and by our primitive knowledge concerning regulation of cell death in these tissues. However, tools are now available to better understand apoptosis in normal and abnormal development of cardiovascular structures, and a framework has been established that should lead to considerable progress in the coming years.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 04:28:25