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Titolo:
Ultrasound for the visualization and quantification of tumor microcirculation
Autore:
Foster, FS; Burns, PN; Simpson, DH; Wilson, SR; Christopher, DA; Goertz, DE;
Indirizzi:
Univ Toronto, Dept Med Imaging, Univ Hlth Network, Toronto, ON, Canada Univ Toronto Toronto ON Canada g, Univ Hlth Network, Toronto, ON, Canada
Titolo Testata:
CANCER AND METASTASIS REVIEWS
fascicolo: 1-2, volume: 19, anno: 2000,
pagine: 131 - 138
SICI:
0167-7659(200006)19:1-2<131:UFTVAQ>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYOCARDIAL PERFUSION; BREAST-CARCINOMA; BLOOD VELOCITY; DOPPLER; ANGIOGENESIS; POWER; FLOW;
Keywords:
angiogensis; microcirculation; ultrasound; microbubble contrast agents; blood flow visualization; Doppler ultrasound; high frequency ultrasound; ultrasound biomicroscopy; three dimensional imaging;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Foster, FS Sunnybrook & Womens Coll Hlth Sci Ctr, Rm S-658,2075 Bayview Av, Toronto, ON M4N 3M5, Canada Sunnybrook & Womens Coll Hlth Sci Ctr Rm S-658,2075 Bayview Av Toronto ON Canada M4N 3M5
Citazione:
F.S. Foster et al., "Ultrasound for the visualization and quantification of tumor microcirculation", CANC METAST, 19(1-2), 2000, pp. 131-138

Abstract

Advances in ultrasound based methods for the non-invasive assessment of the tumor microcirculation are described. Two new ultrasound approaches are highlighted. The first method relies on commercially available ultrasound contrast agents in combination with specialized nonlinear imaging sequences. Nonlinear scattering by microbubble contrast agents provides a unique intravascular signature that can be distinguished from the echoes caused by surrounding tissues. Through destruction-reperfusion experiments it is possibleto use microbubble contrast agents as a tracer revealing the kinetics of tumor blood flow. The second ultrasound method for examining the microcirculation involves the use of much higher frequencies. At frequencies on the order of 50 MHz, Doppler processing allows the direct assessment of flow dynamics in realtime in arterioles as small as 15 mum. Three dimensional Doppler maps of flow patterning are presented. The strengths and weaknesses of these new methods are discussed and the potential for their use in preclinical animal drug studies, clinical drug trials, and prognostic studies is described.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 04:14:59