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Titolo:
Hydration of sickle erythrocytes using a herbal extract (Pfaffia paniculata) in vitro
Autore:
Ballas, SK;
Indirizzi:
Jefferson Med Coll, Cardeza Fdn Hematol Res, Dept Med, Philadelphia, PA 19107 USA Jefferson Med Coll Philadelphia PA USA 19107 , Philadelphia, PA 19107 USA
Titolo Testata:
BRITISH JOURNAL OF HAEMATOLOGY
fascicolo: 1, volume: 111, anno: 2000,
pagine: 359 - 362
SICI:
0007-1048(200010)111:1<359:HOSEUA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL; DEFORMABILITY;
Keywords:
sickle cell anaemia; Pfaffia paniculata; red blood cell deformability; alternative medicine; sodium ionophore;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Ballas, SK Jefferson Med Coll, Cardeza Fdn Hematol Res, Dept Med, 1015 Walnut St, Philadelphia, PA 19107 USA Jefferson Med Coll 1015 Walnut St Philadelphia PA USA 19107 USA
Citazione:
S.K. Ballas, "Hydration of sickle erythrocytes using a herbal extract (Pfaffia paniculata) in vitro", BR J HAEM, 111(1), 2000, pp. 359-362

Abstract

Pfaffia paniculata (PP) is a perennial wild plant that grows in South America. Its root powder has been used by South American Indians for a variety of ailments and has been reported to have a salutary effect on sickle cell disease in Brazil. Its mechanism of action, however, is unknown. In this report, we present experimental data showing that PP improves the deformability of sickle cells, increases their Na+ content and their mean corpuscular volume (MCV). These findings indicate that PP functions as a sodium ionophore on sickle cells and improves their hydration status and rheological properties.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 11:31:53