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Titolo:
Motor cortex excitability in stiff-person syndrome
Autore:
Sandbrink, F; Syed, NA; Fujii, MD; Dalakas, MC; Floeter, MK;
Indirizzi:
NINDS, Electromyog Sect, NIH, Bethesda, MD 20892 USA NINDS Bethesda MD USA 20892 Electromyog Sect, NIH, Bethesda, MD 20892 USA NINDS, Neuromuscular Dis Sect, NIH, Bethesda, MD 20892 USA NINDS BethesdaMD USA 20892 uscular Dis Sect, NIH, Bethesda, MD 20892 USA
Titolo Testata:
BRAIN
, volume: 123, anno: 2000,
parte:, 11
pagine: 2231 - 2239
SICI:
0006-8950(200011)123:<2231:MCEISS>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSCRANIAL MAGNETIC STIMULATION; SILENT PERIOD; CORTICAL EXCITABILITY; CORTICOCORTICAL INHIBITION; SYNAPTIC ORGANIZATION; NEURON EXCITABILITY; EVOKED-RESPONSES; HUMANS; BRAIN; AUTOANTIBODIES;
Keywords:
stiff-person syndrome; transcranial magnetic stimulation; intracortical excitation; intracortical inhibition; silent period;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Floeter, MK 10 Ctr Dr,MSC 1404, Bethesda, MD 20892 USA 10 Ctr Dr,MSC 1404Bethesda MD USA 20892 thesda, MD 20892 USA
Citazione:
F. Sandbrink et al., "Motor cortex excitability in stiff-person syndrome", BRAIN, 123, 2000, pp. 2231-2239

Abstract

Muscle stiffness in stiff-person syndrome (SPS) is produced by continuous,involuntary firing of motor units that is thought to be caused by an autoimmune mediated dysfunction of GABA-ergic inhibitory neurones. We have postulated that the loss of GABA-ergic inputs from spinal interneurones alone isinsufficient to produce tonic firing of motor neurones and that excessive supraspinal excitation could also play a role. To determine whether SPS is associated with dysfunction in supraspinal GABA-ergic neurones, we assessedthe excitability of the motor cortex with transcranial magnetic stimulation (TMS) in seven SPS: patients and seven age-matched healthy volunteers, SPS patients had normal central motor conduction times, normal thresholds formotor evoked potentials (MEPs) in leg muscles, and a normal MEP stimulus versus response recruitment curve with increasing TMS intensities in restinghand and leg muscles. Cortical silent periods were shortened in leg muscles. Intracortical inhibition and excitation were assessed while recording from the abductor pollicis brevis, using a paired pulse TMS paradigm with subthreshold conditioning stimuli, Patients had decreased inhibition and markedly increased facilitation at short intervals. Using paired suprathreshold TMS, patients exhibited increased facilitation at 20- and 40-ms intervals. These results point to a hyperexcitability of the motor cortex in SPS, which could be explained by impairment of supraspinal GABA-ergic neurones, leading to an impaired balance between inhibitory and excitatory intracortical circuitry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 23:11:48