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Titolo:
The functional neuroanatomy of social behaviour - Changes in cerebral blood flow when people with autistic disorder process facial expressions
Autore:
Critchley, HD; Daly, EM; Bullmore, ET; Williams, SCR; Van Amelsvoort, T; Robertson, DM; Rowe, A; Phillips, M; McAlonan, G; Howlin, P; Murphy, DGM;
Indirizzi:
Univ London Kings Coll, Dept Med Psychol, Inst Psychiat, London SE5 8AF, England Univ London Kings Coll London England SE5 8AF t, London SE5 8AF, England Univ London Kings Coll, Dept Neuroimaging, Inst Psychiat, London SE5 8AF, England Univ London Kings Coll London England SE5 8AF t, London SE5 8AF, England St George Hosp, Sch Med, Dept Psychiat, London, England St George Hosp London England , Sch Med, Dept Psychiat, London, England Univ Cambridge, Addenbrookes Hosp, Dept Psychiat, Cambridge CB2 2QQ, England Univ Cambridge Cambridge England CB2 2QQ iat, Cambridge CB2 2QQ, England
Titolo Testata:
BRAIN
, volume: 123, anno: 2000,
parte:, 11
pagine: 2203 - 2212
SICI:
0006-8950(200011)123:<2203:TFNOSB>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFANTILE-AUTISM; ASPERGER-SYNDROME; CHILDHOOD AUTISM; BRAIN; INDIVIDUALS; MIND; ABNORMALITIES; DYSFUNCTION; ACTIVATION; PATHWAY;
Keywords:
Asperger syndrome; attention; autism; facial expression; fMRI;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Murphy, DGM Univ London Kings Coll, Dept Med Psychol, Inst Psychiat, De Crespigny Pk, London SE5 8AF, England Univ London Kings Coll De Crespigny Pk London England SE5 8AF
Citazione:
H.D. Critchley et al., "The functional neuroanatomy of social behaviour - Changes in cerebral blood flow when people with autistic disorder process facial expressions", BRAIN, 123, 2000, pp. 2203-2212

Abstract

Although high-functioning individuals with autistic disorder (i.e. autism and Asperger syndrome) are of normal intelligence,they have life-long abnormalities in social communication and emotional behaviour. However, the biological basis of social difficulties in autism is poorly understood. Facial expressions help shape behaviour, and we investigated if high-functioning people with autistic disorder show neurobiological differences from controlswhen processing emotional facial expressions. We used functional MRI to investigate brain activity in nine adults with autistic disorder (mean age +/- standard deviation 37 +/- 7 years; IQ 102 +/- 15) and nine controls (27 +/- 7 years; IQ 116 +/- 10) when explicitly (consciously) and implicitly (unconsciously) processing emotional facial expressions, Subjects with autistic disorder differed significantly from controls in the activity of cerebellar, mesolimbic and temporal lobe cortical regions of the brain when processing facial expressions. Notably, they did not activate a cortical 'face area' when explicitly appraising expressions, or the left amygdala region and left cerebellum when implicitly processing emotional facial expressions, High-functioning people with autistic disorder have biological differences from controls when consciously and unconsciously processing facial emotions, and these differences are most likely to be neurodevelopmental in origin. This may account for some of the abnormalities in social behaviour associated with autism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/05/20 alle ore 13:22:39