Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
G-CSF plasma levels in clozapine-induced neutropenia
Autore:
Jauss, M; Pantel, J; Werle, E; Schroder, J;
Indirizzi:
Univ Heidelberg, Dept Psychiat, Sect Geriatr Psychiat, Heidelberg, GermanyUniv Heidelberg Heidelberg Germany eriatr Psychiat, Heidelberg, Germany Univ Heidelberg, Med Clin & Policlin, Heidelberg, Germany Univ HeidelbergHeidelberg Germany Clin & Policlin, Heidelberg, Germany
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 11, volume: 48, anno: 2000,
pagine: 1113 - 1115
SICI:
0006-3223(200012)48:11<1113:GPLICN>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY-STIMULATING FACTOR; INDUCED AGRANULOCYTOSIS;
Keywords:
clozapine; neutropenia; granulocyte colony-stimulating factor; granulocytopenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
8
Recensione:
Indirizzi per estratti:
Indirizzo: Jauss, M Univ Giessen, Dept Neurol, Am Steg 14, D-35385 Giessen, Germany Univ Giessen Am Steg 14 Giessen Germany D-35385 Giessen, Germany
Citazione:
M. Jauss et al., "G-CSF plasma levels in clozapine-induced neutropenia", BIOL PSYCHI, 48(11), 2000, pp. 1113-1115

Abstract

Background: Clinical reports emphasize the therapeutic usefulness of granulocyte colony-stimulating factor (G-CSF) in clozapine-induced granulocytopenia. Only sparse information exists, however on the natural course of endogenous G-CSF plasma levels in this condition. Methods: We monitored G-CSF and white blood cell (WBC) counts in a 73-year-old patient who developed granulocytopenia while being treated with clozapine for schizoaffective disorder. Clozapine treatment was discontinued immediately, and G-CSF serum levels were determined repeatedly during the clinical course. Results: Whereas WBC counts increased again within 6 days after discontinuation of clozapine, G-CSF level decreased significantly within the same period. The rapid decrease of endogenous G-CSF levels paralleled by a normalization of neutrophil count was interpreted as the result of an intact regulatory mechanism of granulocytopoesis. Therefore G-CSF therapy was not initiated. Owing to lack of therapeutic alternatives, it was decided to reintroduce clozapine. G-CSF levels decreased further, accompanied by an increase ofWBCs, indicating stable bone marrow functioningConclusions: Based on this observation, we assume that the course of G-CSFand WBC counts indicated an abortive form of toxic bone marrow damage withsubsequent recovery. We conclude that monitoring of G-CSF levels may serveas a useful tool in the follow-up of patients in whom clozapine-induced bone marrow damage is suspected. (C) 2000 Society of Biological Psychiatry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 16:56:04