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Titolo:
Scanning of five chromosomes for alcohol consumption loci
Autore:
Vadasz, C; Saito, M; Gyetvai, B; Mikics, E; Vadasz, C;
Indirizzi:
Nathan S Kline Inst Psychiat Res, Lab Neurobehav Genet, Orangeburg, NY 10962 USA Nathan S Kline Inst Psychiat Res Orangeburg NY USA 10962 rg, NY 10962 USA
Titolo Testata:
ALCOHOL
fascicolo: 1, volume: 22, anno: 2000,
pagine: 25 - 34
SICI:
0741-8329(200008)22:1<25:SOFCFA>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
QUANTITATIVE TRAIT LOCI; RECOMBINANT INBRED MICE; KAPPA-OPIOID RECEPTORS; DISTINCT BRAIN-REGIONS; NEUROTROPHIC FACTOR; GENETIC DISSECTION; PARKINSONS-DISEASE; NUCLEUS-ACCUMBENS; CONGENIC STRAINS; DOPAMINE SYSTEM;
Keywords:
alcohol; Quantitative Trait Loci (QTLs); kappa opioid receptor; mouse strains; voluntary ethanol consumption; Congenic Recombinant QTL Introgression (RQI) strains; microsatellite markers;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Vadasz, C Nathan S Kline Inst Psychiat Res, Lab Neurobehav Genet, 140 Old OrangeburgRd, Orangeburg, NY 10962 USA Nathan S Kline Inst Psychiat Res 140Old Orangeburg Rd Orangeburg NY USA 10962
Citazione:
C. Vadasz et al., "Scanning of five chromosomes for alcohol consumption loci", ALCOHOL, 22(1), 2000, pp. 25-34

Abstract

In our present genetic study to map Quantitative Trait Loci (QTLs) for alcohol-related behaviors, we used 44 B6.C and 36 B6.I inbred congenic Recombinant QTL Introgression (RQI) mouse strains of the b5i7 series carrying genes of BALB/cJ (C) or CXBI (I) origin on C57BL/6ByJ (B6) genetic background. Ethyl alcohol consumption (EAC) was measured in adult males, and chromosomes 1, 2, 3, 9, and 15 were scanned with polymorphic microsatellite markers. In the B6.C set of strains,multiple regression analysis yielded a model with three microsatellite markers, which explained 32% of the genetic variance(p=0.0006). The two markers with the highest significance levels in the model, D1Mit167 and D2Mit74, have been mapped to chromosome regions close to the gene opioid receptor kappa 1 (chr. 1) and opioid receptor kappa 3 (chr.2), respectively. The results of this gene - mapping study suggest that genetic polymorphisms in kappa opioid receptors may contribute to genetic predisposition to voluntary alcohol-drinking behavior. (C) 2000 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 13:25:16