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Titolo:
5-Fluoro-1-octanoyluracil
Autore:
Lehmler, HJ; Parkin, S;
Indirizzi:
Univ Kentucky, Grad Ctr Toxicol, Lexington, KY 40536 USA Univ Kentucky Lexington KY USA 40536 Ctr Toxicol, Lexington, KY 40536 USA Univ Kentucky, Dept Chem, Lexington, KY 40506 USA Univ Kentucky LexingtonKY USA 40506 , Dept Chem, Lexington, KY 40506 USA
Titolo Testata:
ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS
, volume: 56, anno: 2000,
parte:, 11
pagine: E518 - E519
SICI:
0108-2701(200011)56:<E518:5>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CANCER-CHEMOTHERAPY; HUMAN-SKIN; PRO-DRUGS; 5-FLUOROURACIL; DERIVATIVES; DELIVERY; PRODRUGS; 5-FU;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Lehmler, HJ Univ Kentucky, Grad Ctr Toxicol, Lexington, KY 40536 USA Univ Kentucky Lexington KY USA 40536 Lexington, KY 40536 USA
Citazione:
H.J. Lehmler e S. Parkin, "5-Fluoro-1-octanoyluracil", ACT CRYST C, 56, 2000, pp. E518-E519

Abstract

The crystal structure of 5-fluoro-1-octanoyluracil [5-fluoro-1-octanoylpyrimidine-2,4(1H,3H)-dione, C12H17FN2O3], a lipophilic prodrug of 5-fluorouracil, is described. The 5-fluoropyrimidine-2,4(1H,3H)-dione moiety is similar to the known structure of 1-acetyl-5-fluorouracil. The 1-octanoyl group and the 5-fluorouracil moiety are essentially coplanar, with the octanoyl carbonyl group oriented towards the the ring CDH group and away from the nearer ring carbonyl group. The torsion angle C-N-C-O (from the ring CH group to the octanoyl carbonyl group) of 9.2 (2)degrees is similar to the corresponding torsion angles reported for 1-acetyl-5-fluorouracil (17.3 and 1.6 degrees) and 1,3-diacetyl-5-fluorouracil (8.8 degrees).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 07:55:50