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Titolo:
In vitro activities of quinupristin/dalfopristin and eight other antimicrobial agents against 360 clinical isolates from Korea
Autore:
Hwang, SH; Kim, MN; Pai, CH; Huh, DH; Shin, WS;
Indirizzi:
Asan Med Ctr, Dept Clin Pathol, Songpa Gu, Seoul 138736, South Korea Asan Med Ctr Seoul South Korea 138736 ngpa Gu, Seoul 138736, South Korea Univ Ulsan, Coll Med, Dept Clin Pathol, Ulsan 680749, South Korea Univ Ulsan Ulsan South Korea 680749 in Pathol, Ulsan 680749, South Korea Catholic Univ, Coll Med, Clin Res Inst, Seoul, South Korea Catholic Univ Seoul South Korea Med, Clin Res Inst, Seoul, South Korea Catholic Univ, Coll Med, Dept Internal Med, Seoul, South Korea Catholic Univ Seoul South Korea , Dept Internal Med, Seoul, South Korea
Titolo Testata:
YONSEI MEDICAL JOURNAL
fascicolo: 5, volume: 41, anno: 2000,
pagine: 563 - 569
SICI:
0513-5796(200010)41:5<563:IVAOQA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
STAPHYLOCOCCUS-AUREUS; ENTEROCOCCUS-FAECIUM; QUINUPRISTIN-DALFOPRISTIN; BACTERICIDAL ACTIVITY; RAISED MBC; VANCOMYCIN; RESISTANCE; EMERGENCE; RP-59500; STRAINS;
Keywords:
quinupristin/dalfopristin (Q/D); multi-drug resistant; MRSA; enterococci;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Kim, MN Asan Med Ctr, Dept Clin Pathol, Songpa Gu, 388-1 Pungnap Dong, Seoul 138736, South Korea Asan Med Ctr 388-1 Pungnap Dong Seoul South Korea 138736 th Korea
Citazione:
S.H. Hwang et al., "In vitro activities of quinupristin/dalfopristin and eight other antimicrobial agents against 360 clinical isolates from Korea", YONSEI MED, 41(5), 2000, pp. 563-569

Abstract

The emergence of multi-drug resistant gram-positive cocci such as methicillin-resistant (MR) staphylococci, vancomycin-resisrant (VR) enterococci, and vancomycin-intermediate resistant S. aureus (VISA) has given new urgency to the development of new antimicrobial agents. One of these is quinuprisrin/dalfopristin (Q/D). We decided to determine the susceptibility of gram-positive cocci isolated at two university hospitals in Seoul to Q/D and compare the results with eight other antimicrobial agents. We investigated 120 isolates of S. aureus including 49 MRSAs and one VISA, 120 isolates of coagulase negative staphylococci (CNS), 64 E. faecalis and 58 E. faecium, including seven strains of VR E. faecium. Minimum inhibitory concentrations (MICs) and minimal bactericidal concentrations (MBCs) for several antimicrobials, including vancomycin and Q/D, were determined by broth microdilution. AllS. aureus including VISA were susceptible to Q/D. Q/D MIC90 for both methicillin-susceptible S. aureus (MSSA) and MRSA was 0.25 g/mL. 49 (87.5%) of 56 E, faeium including six of seven VR E. faecium were susceptible to Q/D. E. faecalis were not susceptible to Q/D (only 1.5% susceptible), but were inhibited by ampicillin (94% susceptible) or vancomycin (95%). CNS was susceptible to Q/D (96% susceptible) and vancomycin (100% suscepeible). One of 38staphylococci and two of 17 E. faecium were tolerant to QID. In conclusion, Q/D showed excellent activity against all species of gram-positive cocci including MRSA, VISA, and VR E. faecium except E. faecalis, and may providea valuable option for the treatment of infections caused by these emergingnosocomial pathogens of gram-positive cocci.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 07:06:00