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Titolo:
Reproducibility of the six-minute walking test in chronic heart failure patients
Autore:
Pinna, GD; Opasich, C; Mazza, A; Tangenti, A; Maestri, R; Sanarico, M;
Indirizzi:
Med Ctr Montescano, Inst Care & Sci Res, S Maugeri Fdn, Dept Biomed Engn, I-27040 Montescano, PV, Italy Med Ctr Montescano Montescano PV Italy I-27040 7040 Montescano, PV, Italy Med Ctr Montescano, Inst Care & Sci Res, S Maugeri Fdn, Hlth Failure Unit,I-27040 Montescano, PV, Italy Med Ctr Montescano Montescano PV Italy I-27040 7040 Montescano, PV, Italy Noustat Srl, Milan, Italy Noustat Srl Milan ItalyNoustat Srl, Milan, Italy
Titolo Testata:
STATISTICS IN MEDICINE
fascicolo: 22, volume: 19, anno: 2000,
pagine: 3087 - 3094
SICI:
0277-6715(20001130)19:22<3087:ROTSWT>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
MORTALITY; MORBIDITY; DESIGN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Pinna, GD Med Ctr Montescano, Inst Care & Sci Res, S Maugeri Fdn, Dept Biomed Engn, Via Montescano, I-27040 Montescano, PV, Italy Med Ctr Montescano Via Montescano Montescano PV Italy I-27040 ly
Citazione:
G.D. Pinna et al., "Reproducibility of the six-minute walking test in chronic heart failure patients", STAT MED, 19(22), 2000, pp. 3087-3094

Abstract

The six-minute walking test (WT) is used in trials and clinical practice as an easy tool to evaluate the functional capacity of chronic heart failure(CHF) patients. As WT measurements are highly variable both between and within individuals, this study aims at assessing the contribution of the different sources of variation and estimating the reproducibility of the test. A statistical model describing WT measurements as a function of fixed and random effects is proposed and its parameters estimated. We considered 202 stable CHF patients who performed two baseline WTs separated by a 30 minute rest; 49 of them repeated the two tests 3 months later (follow-up control). They had no changes in therapy or major clinical events. Another 31 subjects performed two baseline tests separated by 24 hours. Collected data were analysed using a mixed model methodology. There was no significant difference between measurements taken 30 minutes and 24 hours apart (p =0.99). A trend effect of 17 (1.4) m (mean (SE)) was consistently found between duplicate tests (p < 0.001). REML estimates of variance components were: 5189 (674) for subject differences in the error-free value; 1280 (304) for subject differences in spontaneous clinical evolution between baseline and follow-upcontrol, and 266 (23) for the within-subject error. Hence, the standard error of measurement was 16.3 m, namely 4 per cent of the average WT performance (403 m) in this sample. The intraclass correlation coefficient was 0.96. We conclude that WT measurements are characterized by good intrasubject reproducibility and excellent reliability. When follow-up studies <greater than or equal to>3 months are performed, unpredictable changes in individualwalking performance due to spontaneous clinical evolution are to be expected. Their clinical significance, however, is not known. Copyright (C) 2000 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 13:35:10