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Titolo:
Transport of drugs across the hepatic sinusoidal membrane: Sinusoidal druginflux and efflux in the liver
Autore:
Suzuki, H; Sugiyama, Y;
Indirizzi:
Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan Univ Tokyo Tokyo Japan 1130033 ceut Sci, Bunkyo Ku, Tokyo 1130033, Japan Japan Sci & Technol Corp, Core Res Evolut Sci & Technol, Tokyo, Japan Japan Sci & Technol Corp Tokyo Japan Evolut Sci & Technol, Tokyo, Japan
Titolo Testata:
SEMINARS IN LIVER DISEASE
fascicolo: 3, volume: 20, anno: 2000,
pagine: 251 - 263
SICI:
0272-8087(2000)20:3<251:TODATH>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
ORGANIC ANION TRANSPORTER; ISOLATED RAT HEPATOCYTES; CARRIER-MEDIATED TRANSPORT; PEPTIDIC ENDOTHELIN ANTAGONISTS; RENIN-INHIBITING PEPTIDES; XENOPUS-LAEVIS OOCYTES; BILE-ACID TRANSPORTER; RATE-LIMITING STEP; FUNCTIONAL-CHARACTERIZATION; CATION TRANSPORTER;
Keywords:
organic anion transporting polypeptide; organic anion transporter; organic cation transporter; multi-drug resistance associated protein;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
117
Recensione:
Indirizzi per estratti:
Indirizzo: Sugiyama, Y Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033,Japan Univ Tokyo Tokyo Japan 1130033 nkyo Ku, Tokyo 1130033, Japan
Citazione:
H. Suzuki e Y. Sugiyama, "Transport of drugs across the hepatic sinusoidal membrane: Sinusoidal druginflux and efflux in the liver", SEM LIV DIS, 20(3), 2000, pp. 251-263

Abstract

The liver plays an important role in the detoxification of xenobiotics. Recently, many secondary active transporters responsible for sinusoidal drug uptake have been cloned and their transport properties have been determined. These include rat and human Na+-taurocholate cotransporting polypeptides,rat and human organic anion transporting polypeptides, rat and human prostaglandin transporters, rat organic anion transporters, and rat and human organic cation transporters. In addition, it has been suggested that the expression of multi-drug resistance associated protein 3, a primary active transporter responsible for the cellular extrusion of organic anions, on the sinusoidal membrane is induced under cholestatic conditions. In this article,drug transport across the sinusoidal membrane is summarized, particularly focusing on the molecular mechanism of transport.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 12:52:42