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Titolo:
Protection against cutaneous Leishmaniasis resulting from bites of uninfected sand flies
Autore:
Kamhawi, S; Belkaid, Y; Modi, G; Rowton, E; Sacks, D;
Indirizzi:
NIAID, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA NIAID Bethesda MD USA20892 Parasit Dis Lab, NIH, Bethesda, MD 20892 USA Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Dept Entomol, Washington, DC 20307 USA Walter Reed Army Med Ctr Washington DC USA 20307 Washington, DC 20307 USA
Titolo Testata:
SCIENCE
fascicolo: 5495, volume: 290, anno: 2000,
pagine: 1351 - 1354
SICI:
0036-8075(20001117)290:5495<1351:PACLRF>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL TRANSMISSION; PARASITE TRANSMISSION; LUTZOMYIA-LONGIPALPIS; INTERFERON-GAMMA; VECTOR SALIVA; MICE; DIPTERA; CELLS; PSYCHODIDAE; IMMUNOLOGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Sacks, D NIAID, Parasit Dis Lab, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA NIAID 9000 Rockville Pike Bethesda MD USA 20892 sda, MD 20892 USA
Citazione:
S. Kamhawi et al., "Protection against cutaneous Leishmaniasis resulting from bites of uninfected sand flies", SCIENCE, 290(5495), 2000, pp. 1351-1354

Abstract

Despite the fact that Leishmania are transmitted exclusively by sand flies, none of the experimental models of Leishmaniasis have established infection via sand fly bites. Here we describe a reproducible murine model of Leishmania major infection transmitted by Phlebotomus papatasi. Prior exposure of mice to bites of uninfected sand flies conferred powerful protection against Leishmania major that was associated with a strong delayed-type hypersensitivity response and with interferon-gamma production at the site of parasite delivery. These results have important implications for the epidemiology of cutaneous leishmaniasis and suggest a vaccination strategy against this and possibly other vector-borne diseases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 20:37:11