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Titolo:
DISTINCT ELECTROPHYSIOLOGICAL EFFECTS OF 2 SPINALLY ADMINISTERED MEMBRANE STABILIZING DRUGS, BUPIVACAINE AND LAMOTRIGINE
Autore:
CHAPMAN V; WILDMAN MA; DICKENSON AH;
Indirizzi:
UNIV LONDON UNIV COLL,DEPT PHARMACOL,GOWER ST LONDON WC1E 6BT ENGLAND
Titolo Testata:
Pain
fascicolo: 3, volume: 71, anno: 1997,
pagine: 285 - 295
SICI:
0304-3959(1997)71:3<285:DEEO2S>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
POTENTIAL ANTIEPILEPTIC DRUG; DORSAL HORN; NOCICEPTIVE NEURONS; SYSTEMIC LIDOCAINE; NEUROPATHIC RATS; SODIUM-CHANNELS; NMDA RECEPTOR; WIND-UP; CORD; ANESTHESIA;
Keywords:
BUPIVACAINE; LAMOTRIGINE; SPINAL CORD; RAT; NOCICEPTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
V. Chapman et al., "DISTINCT ELECTROPHYSIOLOGICAL EFFECTS OF 2 SPINALLY ADMINISTERED MEMBRANE STABILIZING DRUGS, BUPIVACAINE AND LAMOTRIGINE", Pain, 71(3), 1997, pp. 285-295

Abstract

A selective blockade of the relay of messages by C-fibres into the spinal cord is a logical approach to the reduction of nociceptive transmission. Here we compared the effect of two distinctly different sodiumchannel blockers, the local anaesthetic bupivacaine and the novel anti-epileptic lamotrigine, on the responses of dorsal horn neurones following noxious and innocuous stimulation. Dorsal horn neuronal responses following acute repetitive C-fibre electrical stimulation (three times the C-fibre threshold at 0.5 Hz) were recorded in intact halothane anaesthetised rats. Wind up, an enhanced C-fibre evoked response of dorsal horn neurones, and an associated post discharge were observed following repetitive stimulation. The effects of spinally administered bupivacaine and lamotrigine on the dorsal horn neuronal responses were investigated. Spinal bupivacaine (25-1000 mu g/50 mu l) dose dependently reduced the C-fibre evoked responses (r(2) = 0.5, P < 0.0003), wind up (r(2) = 0.4, P < 0.002) and the post discharge (r(2) = 0.34, P < 0.005) of these neurones. The effects of bupivacaine were long lasting, up to 120 min post-administration. The A beta-fibre evoked responses were not dose-dependently reduced by bupivacaine. Spinal lamotrigine (50-1000 mu g/50 mu l) did not significantly reduce the C- or A beta-fibre evoked responses. In contrast there was a tendency for wind up and post discharge to be facilitated by lamotrigine. Although both bupivacaine and lamotrigine are sodium channel blockers, the effects of the two drugs on the C-fibre and A beta-fibre evoked responses were completely different. Bupivacaine reduced C-fibre evoked responses whereas lamotrigine had a tendency to facilitate responses. The profile of sodium channel blockers would appear highly diverse and the status of lamotrigine as a potential analgesic remains unclear. (C) 1997 International Association for the Study of Pain. Published by Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 00:38:05