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Titolo:
Renal and immunologic markers for chloralkali workers with low exposure tomercury vapor
Autore:
Ellingsen, DG; Efskind, J; Berg, KJ; Gaarder, PI; Thomassen, Y;
Indirizzi:
Natl Inst Occupat Hlth, N-0033 Oslo, Norway Natl Inst Occupat Hlth Oslo Norway N-0033 upat Hlth, N-0033 Oslo, Norway Borregaard Ind Ltd, Dept Hlth, Sarpsborg, Norway Borregaard Ind Ltd Sarpsborg Norway d Ltd, Dept Hlth, Sarpsborg, Norway Univ Oslo, Rikshosp, Dept Med B, Nephrol Sect, N-0027 Oslo, Norway Univ Oslo Oslo Norway N-0027 pt Med B, Nephrol Sect, N-0027 Oslo, Norway Ulleval Univ Hosp, Dept Immunol & Transfus Med, Oslo, Norway Ulleval Univ Hosp Oslo Norway Dept Immunol & Transfus Med, Oslo, Norway
Titolo Testata:
SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH
fascicolo: 5, volume: 26, anno: 2000,
pagine: 427 - 435
SICI:
0355-3140(200010)26:5<427:RAIMFC>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMA GLUTATHIONE-PEROXIDASE; ANTI-LAMININ ANTIBODIES; INORGANIC MERCURY; ANTINUCLEAR ANTIBODIES; ELEMENTAL MERCURY; AUTOANTIBODIES; SELENIUM; NEPHROTOXICITY; COMPLEXES; TOXICITY;
Keywords:
autoantibodies to myeloperoxidase; urinary N-acetyl-beta-D-glucosaminidase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Ellingsen, DG Natl Inst Occupat Hlth, POB Box 8149 Dep, N-0033 Oslo, Norway Natl Inst Occupat Hlth POB Box 8149 Dep Oslo Norway N-0033
Citazione:
D.G. Ellingsen et al., "Renal and immunologic markers for chloralkali workers with low exposure tomercury vapor", SC J WORK E, 26(5), 2000, pp. 427-435

Abstract

Objectives The aim of this study was to investigate renal function and immunologic markers among chloralkali workers with long-term low exposure to mercury vapor. Methods Forty-seven currently exposed workers were compared with referenceworkers matched for age in a cross-sectional design. Results The mean urinary mercury concentration was 5.9 (range 1.1-16.8) nmol/mmol creatinine (Cr) for the exposed workers and 1.3 (range 0.2-5.0) nmol/mmol Cr for the referents. The chloralkali workers had been exposed for an average of 13.3 (range 2.8-34.5) years. The activity of N-acetyl-beta -D-glucosaminidase in urine (U- NAG) was higher in the exposed workers (mean 0.18 U/mmol Cr versus 0.14 U/mmol Cr, P=0.02). Associations between current urinary mercury, cumulative urinary mercury, and cumulative urinary mercuryper year (intensity) and U-NAG, autoantibodies to myeloperoxidase (anti-MPO) and proteinase 3 in serum, respectively, were observed. The activity of U-NAG and anti-MPG was increased in the workers with the highest exposure, as assessed by their mean intensity of exposure. The highest activity of U-NAG was observed in the exposed workers with the lower concentrations of selenium in whole blood. Conclusions The study indicates an effect of exposure on the kidney proximale tubule cells, possibly modified by individual selenium status, and an effect mediated by neutrophil granulocytes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/11/20 alle ore 21:33:04