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Titolo:
Relation between myofibers and connective tissue during muscle injury repair
Autore:
Kaariainen, M; Jarvinen, T; Jarvinen, M; Rantanen, J; Kalimo, H;
Indirizzi:
Turku Univ Hosp, Dept Pathol, FIN-20520 Turku, Finland Turku Univ Hosp Turku Finland FIN-20520 Pathol, FIN-20520 Turku, Finland Univ Tampere, Sch Med, FIN-33101 Tampere, Finland Univ Tampere Tampere Finland FIN-33101 h Med, FIN-33101 Tampere, Finland Univ Tampere, Inst Med Technol, FIN-33101 Tampere, Finland Univ Tampere Tampere Finland FIN-33101 chnol, FIN-33101 Tampere, Finland Tampere Univ Hosp, Dept Surg, Sect Orthopaed, Tampere, Finland Tampere Univ Hosp Tampere Finland urg, Sect Orthopaed, Tampere, Finland Turku Univ Hosp, Dept Surg, FIN-20520 Turku, Finland Turku Univ Hosp Turku Finland FIN-20520 t Surg, FIN-20520 Turku, Finland Univ Turku, Paavo Nurmi Ctr, Turku, Finland Univ Turku Turku FinlandUniv Turku, Paavo Nurmi Ctr, Turku, Finland
Titolo Testata:
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
fascicolo: 6, volume: 10, anno: 2000,
pagine: 332 - 337
SICI:
0905-7188(200012)10:6<332:RBMACT>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
SKELETAL-MUSCLE; ALPHA-7-BETA-1 INTEGRIN; GASTROCNEMIUS-MUSCLE; REGENERATION; CELLS; FIBRONECTIN; EXPRESSION; JUNCTIONS; ADHESION; COLLAGEN;
Keywords:
connective tissue; myofibers; skeletal muscle; muscle injury; muscle repair; adhesion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Kalimo, H Turku Univ Hosp, Dept Pathol, Kiinamyllynkatu 10, FIN-20520 Turku, Finland Turku Univ Hosp Kiinamyllynkatu 10 Turku Finland FIN-20520 land
Citazione:
M. Kaariainen et al., "Relation between myofibers and connective tissue during muscle injury repair", SC J MED SC, 10(6), 2000, pp. 332-337

Abstract

The connective tissue framework in skeletal muscle combines the contractile myofibers into a functional unit, in which the contraction of myofibers is transformed into movement via myotendinous junctions (MTJs) at their ends, where myofibers attach to tendons/fascia. The cytoskeletal contractile myofilament apparatus adheres through subsarcolemmal and transmembrane molecules to the surrounding extracellular matrix, with integrin and dystrophin associated chains of molecules being the two main adhesion complexes. In shearing type of muscle injury both myofibers and the connective tissue framework are ruptured and thereby the functional tendon-muscle-tendon units are disrupted. The stumps of the ruptured myofibers are separated and at the same time joined by a connective tissue scar, through which the ends of regenerating myofibers try to pierce, but as the scar becomes more compact the ends attach to the scar by new mini-MTJs. During the early phase ruptured myofibers try to compensate for the lost MTJ attachment by reinforcing their integrin mediated lateral adhesion, which returns to normal low level afterformation of the mini-MTJs and at which time complementary increase of dystrophin and associated molecules on lateral sarcolemma takes place. The stumps appear to remain separated by and attached to the interposed scar for many months, possibly for ever, i.e. the original tendon-muscle-tendon unitsmay have become permanently divided into two consecutive units. Remarkably, axon sprouts are able to penetrate through the interposed scar to form new neuromuscular junctions on those abjunctional stumps which were denervated by the rupture.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 08:34:43