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Titolo:
The NPY effects on murine leukocyte adherence and chemotaxis change with age - Adherent cell implication
Autore:
Medina, S; Del Rio, M; Hernanz, A; De la Fuente, M;
Indirizzi:
Univ Complutense, Fac Biol Sci, Dept Anim Physiol, E-28040 Madrid, Spain Univ Complutense Madrid Spain E-28040 nim Physiol, E-28040 Madrid, Spain Hosp La Paz, Serv Biochem, Madrid, Spain Hosp La Paz Madrid SpainHosp La Paz, Serv Biochem, Madrid, Spain
Titolo Testata:
REGULATORY PEPTIDES
fascicolo: 1-3, volume: 95, anno: 2000,
pagine: 35 - 45
SICI:
0167-0115(20001124)95:1-3<35:TNEOML>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
GASTRIN-RELEASING PEPTIDE; PROTEIN-KINASE-C; SULFATED CHOLECYSTOKININ-OCTAPEPTIDE; NEUROPEPTIDE-Y; SUBSTANCE-P; IMMUNE-SYSTEM; NEUROMEDIN-C; RAT SPLEEN; T-CELLS; MODULATION;
Keywords:
leukocyte functions; neuropeptide Y; ageing; mice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: De la Fuente, M Univ Complutense, Fac Biol Sci, Dept Anim Physiol, Av Complutense S-N, E-28040 Madrid, Spain Univ Complutense Av Complutense S-N Madrid Spain E-28040
Citazione:
S. Medina et al., "The NPY effects on murine leukocyte adherence and chemotaxis change with age - Adherent cell implication", REGUL PEPT, 95(1-3), 2000, pp. 35-45

Abstract

The two-way communication between the nervous and immune system is currently well-known, but the age-related changes in this communication have been scarcely studied. In the present work, we have investigated the in vitro effects of neuropeptide Y (NPY) at concentrations ranging from 10(-13) to 10(-7) M on the adherence and chemotaxis capacities of spleen, axillary node, thymus and peritoneum leukocytes from BALB/c mice. The NPY effect on these functions was examined on cells from animals of four different ages, i.e. young (12+/-2 weeks old), adult (24+/-2 weeks old), mature (50+/-2 weeks old) and old (72+/-2 weeks old). In young animals, NPY stimulates the adherence of leukocytes from spleen, axillary nodes and thymus and inhibits it in cells from peritoneum. In adult animals NPY inhibits the adherence of leukocytes from thymus. These effects disappear with ageing in all locations. Chemotaxis is stimulated by this neuropeptide at all ages in cells from axillary nodes and peritoneum, but this effect is absent in old mice. NPY exerts an inhibitory effect on the chemotaxis of leukocytes from thymus at all ages studied. These NPY effects on leukocytes seem to be carried out through adherent cells. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 19:29:50