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Titolo:
Biocompatible elastomers composed of segmented polyurethane and 2-methacryloyloxyethyl phosphorylcholine polymer
Autore:
Ishihara, K; Iwasaki, Y;
Indirizzi:
Univ Tokyo, Grad Sch Engn, Dept Mat Sci, Bunkyo Ku, Tokyo 1138656, Japan Univ Tokyo Tokyo Japan 1138656 Mat Sci, Bunkyo Ku, Tokyo 1138656, Japan Tokyo Med & Dent Univ, Inst Biomat & Bioengn, Chiyoda Ku, Tokyo 1100062, Japan Tokyo Med & Dent Univ Tokyo Japan 1100062 iyoda Ku, Tokyo 1100062, Japan
Titolo Testata:
POLYMERS FOR ADVANCED TECHNOLOGIES
fascicolo: 8-12, volume: 11, anno: 2000,
pagine: 626 - 634
SICI:
1042-7147(200008/12)11:8-12<626:BECOSP>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHOSPHOLIPID POLYMERS; BLOOD COMPATIBILITY; PROTEIN ADSORPTION; PLATELET-ADHESION; SURFACE; HEMOCOMPATIBILITY; MEMBRANES; PLASMA;
Keywords:
phospholipid polymer; segmented polyurethane; biocompatibility; blending; medical elastomer;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Ishihara, K Univ Tokyo, Grad Sch Engn, Dept Mat Sci, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138656, Japan Univ Tokyo 7-3-1 Hongo Tokyo Japan 1138656 kyo 1138656, Japan
Citazione:
K. Ishihara e Y. Iwasaki, "Biocompatible elastomers composed of segmented polyurethane and 2-methacryloyloxyethyl phosphorylcholine polymer", POLYM ADV T, 11(8-12), 2000, pp. 626-634

Abstract

To improve the biocompatibility of a segmented polyurethane (SPU), 2-methacryloyloxyethyl phosphorylcholine (MPC) copolymer was blended in the SPUs, such as Pellethane(R) and TM-3(R) by a solvent evaporation method from a homogeneous solution containing both SPU and MPC copolymer. X-my electron spectra indicated that the MPC moieties were located at the surface of the SPUmembrane blended with the MPC copolymer Even when the composition of the MPC copolymer was only 7.5 w/w % against the matrix SPU. The mechanical property of the SPU membranes, as determined by tensile stress-strain measurements, changed very little by addition of the MPC copolymer. Biocompatibilityof the MPC copolymer blended membrane was evaluated by plasma protein adsorption and blood cell adhesion on the surface. The amount of fibrinogen adsorbed on the SPU membrane significantly decreased by addition of the MPC copolymers. Moreover, addition of MPC copolymer in the SPU membrane suppressed platelet adhesion and activation. Tf is concluded that the blending of the MPC copolymer in the SPU membrane is an effective method to improve biocompatibility of the SPU membrane. Copyright (C) 2000 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 07:39:26