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Titolo:
The role of sensory neurons in the antiulcer effect of centrally injected amylin in rat
Autore:
Guidobono, F; Pagani, F; Sibilia, V; Soglian, A; Rapetti, D; Netti, C;
Indirizzi:
Univ Milan, Dept Pharmacol Chemotherapy & Med Toxicol, I-20129 Milan, Italy Univ Milan Milan Italy I-20129 erapy & Med Toxicol, I-20129 Milan, Italy
Titolo Testata:
PEPTIDES
fascicolo: 10, volume: 21, anno: 2000,
pagine: 1537 - 1541
SICI:
0196-9781(200010)21:10<1537:TROSNI>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-RELATED PEPTIDE; ISLET AMYLOID POLYPEPTIDE; INDUCED LESION FORMATION; GASTRIC-ACID SECRETION; TREATED RATS; CAPSAICIN; INDOMETHACIN; INVOLVEMENT; AFFERENT; RELEASE;
Keywords:
amylin; ulcers; indomethacin; capsaicin; yohimbine; CGRP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Guidobono, F Univ Milan, Dept Pharmacol Chemotherapy & Med Toxicol, Via Vanvitelli 32, I-20129 Milan, Italy Univ Milan Via Vanvitelli 32 Milan ItalyI-20129 ilan, Italy
Citazione:
F. Guidobono et al., "The role of sensory neurons in the antiulcer effect of centrally injected amylin in rat", PEPTIDES, 21(10), 2000, pp. 1537-1541

Abstract

Central administration of amylin (2.2 mug/rat, i.c.v.) reduces (from a minimum of 67% to 83%) indomethacin (Indo, 20 mg Kg(-1), orally) induced ulcers in rats. The anti-ulcer effect of the peptide is not removed by the administration of prokinetic drugs like domperidone or neostigmine but it is reduced by 35% in rats treated with capsaicin or with the CGRP antagonist, CGRP(8-37). These data indicate that amylin gastroprotection involves capsaicin-sensitive nerve fiber leading to CGRP-dependent gastric vasodilatory effect. Additional mechanisms could involve noradrenergic alpha (2) receptors as the peptide gastroprotective activity is reduced from 67% to 20% by the alpha (2) antagonist yohimbine. (C) 2000 Elsevier Science Inc, All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 13:05:06