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Titolo:
Abnormal synaptic organization between granule cells and Purkinje cells inthe new ataxic mutant mouse, pogo
Autore:
Jeong, YG; Hyun, BH;
Indirizzi:
Konyang Univ, Coll Med, Dept Anat, Nonsan 320711, Chungnam, South Korea Konyang Univ Nonsan Chungnam South Korea 320711 11, Chungnam, South Korea Korea Inst Biosci & Biotechnol, Genet Resource Ctr, KRIBB, Taejon 305333, South Korea Korea Inst Biosci & Biotechnol Taejon South Korea 305333 33, South Korea
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 2, volume: 294, anno: 2000,
pagine: 77 - 80
SICI:
0304-3940(20001117)294:2<77:ASOBGC>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Keywords:
ataxic mutant; cerebellum; parallel fiber; purkinje cell dendritic spine; ectopic spine; abnormal synapse; electron microscopy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Jeong, YG Univ Calgary, Fac Med, Dept Cell Biol & Anat, Genes & Dev Res Grp, Calgary, AB T2N 4N1, Canada Univ Calgary Calgary AB Canada T2N 4N1 gary, AB T2N 4N1, Canada
Citazione:
Y.G. Jeong e B.H. Hyun, "Abnormal synaptic organization between granule cells and Purkinje cells inthe new ataxic mutant mouse, pogo", NEUROSCI L, 294(2), 2000, pp. 77-80

Abstract

The pogo mouse is a new ataxic mutant derived from the Korean wild mouse. The pathological manifestations include difficulty in maintaining normal posture and the inability to walk straight. The ataxia becomes apparent at about 2 weeks of age. Electron microscopic studies of the pogo/pogo homozygous cerebellum, revealed that the ectopic spines emanating from the primary dendrite of Purkinje cells were observed. Major difference between pogo/pogohomozygous and non-affected pogo/+ heterozygous was the synaptic organization of the molecular layer. Parallel fiber varicosities were larger than normal and a single fiber often established synaptic contacts with up to fourdendritic spines of a Purkinje cell. This correlation between the presenceof altered synaptic organization in the cerebellum and ataxia in pogo/pogomutant mice warrants further investigation. (C) 2000 Published by ElsevierScience Ireland Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 08:08:12