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Titolo:
Neurotoxicity of NAAG in vivo is sensitive to NMDA antagonists and mGluR II ligands
Autore:
Pliss, L; FitzGibbon, T; Balcar, VJ; Stastny, F;
Indirizzi:
Acad Sci Czech Republ, Inst Physiol, Dept Mol Neurobiol, CZ-14220 Prague 4, Czech Republic Acad Sci Czech Republ Prague Czech Republic 4 0 Prague 4, Czech Republic Univ Sydney, Dept Anat & Histol, Sydney, NSW 2006, Australia Univ Sydney Sydney NSW Australia 2006 Histol, Sydney, NSW 2006, Australia Univ Sydney, Inst Biomed Res, Sydney, NSW 2006, Australia Univ Sydney Sydney NSW Australia 2006 ed Res, Sydney, NSW 2006, Australia
Titolo Testata:
NEUROREPORT
fascicolo: 16, volume: 11, anno: 2000,
pagine: 3651 - 3654
SICI:
0959-4965(20001109)11:16<3651:NONIVI>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
METABOTROPIC GLUTAMATE RECEPTORS; ACETYL-ASPARTYL-GLUTAMATE; QUINOLINIC ACID LESIONS; RAT-BRAIN; IN-VITRO; PROTECTS; NEURONS; AGONIST; EXCITOTOXICITY; ACTIVATION;
Keywords:
CGS 19755; DCG IV; EGlu; group II metabotropic glutamate receptors; MK-801; N-acetyl-aspartyl-glutamate; neurotoxicity; NMDA receptors; quinolinic acid;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Pliss, L Acad Sci Czech Republ, Inst Physiol, Dept Mol Neurobiol, Videoska1083, CZ-14220 Prague 4, Czech Republic Acad Sci Czech Republ Videoska 1083 Prague Czech Republic 4 blic
Citazione:
L. Pliss et al., "Neurotoxicity of NAAG in vivo is sensitive to NMDA antagonists and mGluR II ligands", NEUROREPORT, 11(16), 2000, pp. 3651-3654

Abstract

N-Acetyl-aspartyl-glutamate (NAAG), an agonist at Group II metabotropic glutamate receptors (mGluR II), also activates the NMDA-type of ionotropic glutamate receptors and. at high micromolar concentrations, has previously been shown to induce neuronal cell death. In the present study we have morphologically quantified the neurotoxic action of intracerebroventricularly administered NAAG on the hippocampal formation and compared it to the action of the selective endogenous NMDA agonist quinolinic acid. Finally, we examined whether the action of NAAG can be modified by NMDA receptor antagonists and mGluR It ligands. NAAG-induced neurodegeneration was found to be less severe than that induced by quinolinate. It was prevented by inhibitors of NMDA receptors and also by an mGluR II agonist (DCG IV) but not by an mGluR II antagonist (EGlu). NeuroReport 11:3651-3654 (C) 2000 Lippincott Williams& Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 11:46:08