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Titolo:
Expression of a system L neutral amino acid transporter at the blood-brainbarrier
Autore:
Matsuo, H; Tsukada, S; Nakata, T; Chairoungdua, A; Kim, DK; Cha, SH; Inatomi, J; Yorifuji, H; Fukuda, J; Endou, H; Kanai, Y;
Indirizzi:
Kyorin Univ, Sch Med, Dept Pharmacol & Toxicol, Tokyo 1818611, Japan Kyorin Univ Tokyo Japan 1818611 harmacol & Toxicol, Tokyo 1818611, Japan Natl Def Med Coll, Dept Physiol 1, Tokorozawa, Saitama 3598513, Japan NatlDef Med Coll Tokorozawa Saitama Japan 3598513 Saitama 3598513, Japan Natl Def Med Coll, Dept Anat, Tokorozawa, Saitama 3598513, Japan Natl Def Med Coll Tokorozawa Saitama Japan 3598513 Saitama 3598513, Japan PRESTO, Japan Sci & Technol Corp, Kyoto, Japan PRESTO Kyoto JapanPRESTO, Japan Sci & Technol Corp, Kyoto, Japan
Titolo Testata:
NEUROREPORT
fascicolo: 16, volume: 11, anno: 2000,
pagine: 3507 - 3511
SICI:
0959-4965(20001109)11:16<3507:EOASLN>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL ACTIVATION; IDENTIFICATION; GLYCOPROTEIN; CAPILLARIES; METABOLISM; CLONING;
Keywords:
amino acid; blood-brain barrier; L-DOPA; 4F2 heavy chain; system L; transporter;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Kanai, Y Kyorin Univ, Sch Med, Dept Pharmacol & Toxicol, 6-20-2 Shinkawa, Tokyo 1818611, Japan Kyorin Univ 6-20-2 Shinkawa Tokyo Japan 1818611 o 1818611, Japan
Citazione:
H. Matsuo et al., "Expression of a system L neutral amino acid transporter at the blood-brainbarrier", NEUROREPORT, 11(16), 2000, pp. 3507-3511

Abstract

Amino acid transport system L has been proposed to be one of the major nutrient transport systems at the blood-brain barrier. Using immunohistochemical analyses, a system L transporter LAT1 was shown to be expressed in the brain capillary endothelial cells in rats. Because LAT1 was coexpressed with4F2 heavy chain which brings LAT1 to the plasma membrane, LAT1 is proposedto be functional in the plasma membrane of brain capillary endothelial cells. Both LAT1 and 4F2hc immunoreactivities were detected in-a double line appearance surrounding endothelial cell nuclei, suggesting both proteins arepresent in the luminal and abluminal membranes. LAT1 is, thus, a blood-brain-barrier system L transporter responsible for the permeation of aromatic or branched-chain amino acids and amino acid-related drugs such as L-DOPA. NeuroReport 11:3507-3511 (C) 2000 Lippincott Williams & Wilkins.

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Documento generato il 28/01/21 alle ore 07:50:17