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Titolo:
In vivo measurement of the vesicular monoamine transporter in schizophrenia
Autore:
Taylor, SF; Koeppe, RA; Tandon, R; Zubieta, JK; Frey, KA;
Indirizzi:
Univ Michigan, Med Ctr, Dept Psychiat, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 pt Psychiat, Ann Arbor, MI 48109 USA Univ Michigan, Dept Internal Med, Div Nucl Med, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 iv Nucl Med, Ann Arbor, MI 48109 USA Univ Michigan, Dept Neurol, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 Dept Neurol, Ann Arbor, MI 48109 USA Univ Michigan, Mental Hlth Res Inst, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 th Res Inst, Ann Arbor, MI 48109 USA
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 6, volume: 23, anno: 2000,
pagine: 667 - 675
SICI:
0893-133X(200012)23:6<667:IVMOTV>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; DOPAMINE-RECEPTOR-BINDING; AMINO-ACID DECARBOXYLASE; AGE-RELATED-CHANGES; PREFRONTAL CORTEX; HUMAN-BRAIN; C-11 DIHYDROTETRABENAZINE; COMPUTERIZED-TOMOGRAPHY; AMPHETAMINE PSYCHOSIS; SUBSTANTIA-NIGRA;
Keywords:
schizophrenia; dopamine; tetrabenazine; synaptic vesicles; emission computed tomography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Taylor, SF Univ Michigan, Med Ctr, Dept Psychiat, UH 9D Box 0118,1500 E Med Ctr Dr, Ann Arbor, MI 48109 USA Univ Michigan UH 9D Box 0118,1500 E Med Ctr Dr Ann Arbor MI USA 48109
Citazione:
S.F. Taylor et al., "In vivo measurement of the vesicular monoamine transporter in schizophrenia", NEUROPSYCH, 23(6), 2000, pp. 667-675

Abstract

Given evidence for excessive striatal dopamine activity in schizophrenia, we sought to test the hypothesis that dopaminergic innervation in the striatum is a abnormally elevated, and a secondary hypothesis that age-related loss is accelerated. Twelve schizophrenic subjects on stable doses of medications, along with 12 age and sex-matched healthy control subjects, underwent positron emission tomography (PET) studies with [C-11]dihydrotetrabenazine (DTBZ), which binds to the vesicular monamine transporter, type 2 (VMAT2). DTBZ binding reflects principally dopaminergic projections in the striatum and appears in animal models, over treatment periods as long as two weeks, not to be regulated by antipsychotic drugs. Using an equilibrium analysis, we obtained measurements of the bindingpotential (BP) of [C-11]DTBZ, as well as a transport (K-1) measure, corresponding to regional cerebral blood flow. BP in the striatum sh owed no difference between the patient and control groups, and no differential effect of age. We did not find evidence supporting the hypothesis that excessive dopamine activity in schizophrenia could be explained by increased density of striatal dopamine terminals. (C) 2000 American College of Neuropsychopharmacology. Published by Elsevier Science Inc. All rights reserved.

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Documento generato il 15/07/20 alle ore 04:42:28