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Titolo:
Birth insult alters dopamine-mediated behavior in a precocial species, theguinea pig: Implications for schizophrenia
Autore:
Vaillancourt, C; Boksa, P;
Indirizzi:
McGill Univ, Douglas Hosp, Res Ctr, Dept Psychiat, Verdun, PQ H4H 1R3, Canada McGill Univ Verdun PQ Canada H4H 1R3 Psychiat, Verdun, PQ H4H 1R3, Canada McGill Univ, Douglas Hosp, Res Ctr, Dept Neurol & Neurosurg, Verdun, PQ H4H 1R3, Canada McGill Univ Verdun PQ Canada H4H 1R3 eurosurg, Verdun, PQ H4H 1R3, Canada
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 6, volume: 23, anno: 2000,
pagine: 654 - 666
SICI:
0893-133X(200012)23:6<654:BIADBI>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
CESAREAN-SECTION BIRTH; PERINATAL RISK-FACTORS; PREPULSE INHIBITION; NUCLEUS-ACCUMBENS; LOCOMOTOR-ACTIVITY; ACOUSTIC STARTLE; VAGINAL BIRTH; OBSTETRIC COMPLICATIONS; MATERNAL SEPARATION; GENERAL-ANESTHESIA;
Keywords:
amphetamine; caesarean section; dopamine; guinea pig; locomotion; perinatal hypoxia; prepulse inhibition; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
66
Recensione:
Indirizzi per estratti:
Indirizzo: Boksa, P McGill Univ, Douglas Hosp, Res Ctr, Dept Psychiat, 6875 LaSalle Blvd, Verdun, PQ H4H 1R3, Canada McGill Univ 6875 LaSalle Blvd Verdun PQ Canada H4H 1R3 R3, Canada
Citazione:
C. Vaillancourt e P. Boksa, "Birth insult alters dopamine-mediated behavior in a precocial species, theguinea pig: Implications for schizophrenia", NEUROPSYCH, 23(6), 2000, pp. 654-666

Abstract

Schizophrenia is associated with increased birth complications, suggestingthat birth complications might alter CNS dopaminergic activity later in life. In mts, Caesarean section (C-section) birth can produce long term changes in dopaminergic biochemistry and behavior. However rat brain is somewhatimmature compared to human brain at birth. The current study tested if mild birth complications also alter dopamine-mediated function in a species with a more mature CNS at birth, the guinea pig. As adults, guinea pigs born by C-section showed increased amphetamine-induced locomotion and disruptionof prepulse inhibition (PPI) of acoustic startle, compared to vaginally born controls. Guinea pigs born by C-section with 1 min of added global anoxia showed reduced amphetamine- induced locomotion and disrupted PPI, while aC-section plus 2 min anoxia group shouted no change in amphetamine-inducedlocomotion but increased amphetamine-induced startle. No group differencesin effects of amphetamine ol apomorphine on PPI were observed. Taken with previous findings, these results indicate that mild birth complications cancause long term changes in dopamine-mediated behavior in both guinea pig and rat, two species spanning the level of human brain maturity at birth. (C) 2000 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 00:39:31