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Titolo:
Involvement of the nucleus accumbens and medial prefrontal cortex in the expression of conditioned hyperactivity to a cocaine-associated environment in rats
Autore:
Franklin, TR; Druhan, JP;
Indirizzi:
Univ Penn, Sch Med, Dept Psychiat, Ctr Neurobiol & Behav, Philadelphia, PA19104 USA Univ Penn Philadelphia PA USA 19104 ol & Behav, Philadelphia, PA19104 USA MCPHU, Grad Program Neurosci, Philadelphia, PA USA MCPHU Philadelphia PA USA U, Grad Program Neurosci, Philadelphia, PA USA
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 6, volume: 23, anno: 2000,
pagine: 633 - 644
SICI:
0893-133X(200012)23:6<633:IOTNAA>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOPAMINE OXIDATION CURRENTS; INDUCED LOCOMOTOR-ACTIVITY; PAVLOVIAN HEART-RATE; PLACE PREFERENCE; BASOLATERAL AMYGDALA; D-AMPHETAMINE; EXCITOTOXIC LESIONS; RECEPTOR ANTAGONIST; MESOLIMBIC DOPAMINE; INTRAVENOUS COCAINE;
Keywords:
pavlovian conditioning; drug abuse; GABA agonist; cingulate cortex; locomotion; rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Druhan, JP VA Med Ctr, Mail Code 151,Univ & Woodland Ave, Philadelphia, PA19104 USA VA Med Ctr Mail Code 151,Univ & Woodland Ave Philadelphia PA USA19104
Citazione:
T.R. Franklin e J.P. Druhan, "Involvement of the nucleus accumbens and medial prefrontal cortex in the expression of conditioned hyperactivity to a cocaine-associated environment in rats", NEUROPSYCH, 23(6), 2000, pp. 633-644

Abstract

This study examined the roles of the nucleus accumbens (NAc), medial prefrontal cortex, basolateral amygdala, and ventral subiculum of the hippocampus in the expression of Pavlovian conditioned hyperactivity responses to cocaine-related stimuli. This was accomplished by pharmacologically inhibitingthese regions prior to drug-free tests for conditioned hyperactivity in anenvironment previously associated with cocaine. The results indicate that conditioned hyperactivity could be disrupted by infusions of the GABA-B agonist, baclofen (0.2 nmol/0.5 mul/side) into the NAc, or completely blocked by infusions of the GABA-A agonist, muscimol (0.1 and 0.2 nmol/0.5 mul/side) into the medial prefrontal cortex. In contrast, conditioned hyperactivitywas unaffected by pharmacological inhibition of the basolateral amygdala, the ventral subiculum, or sites dorsal to the NAc or prefrontal cortex. These findings suggest that the NAc and the prefrontal cortex are crucial elements of the neural circuitry underlying the expression of Pavlovian conditioned responses to cocaine-related stimuli. (C) 2000 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

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Documento generato il 25/01/20 alle ore 04:01:30